Effect of mRNA Diffusion on Stochastic Bursts in Gene Transcription Full article
Journal |
Journal of Experimental and Theoretical Physics Letters (JETP Letters)
ISSN: 0021-3640 , E-ISSN: 1090-6487 |
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Output data | Year: 2007, Volume: 85, Number: 6, Pages: 302-305 Pages count : 4 DOI: 10.1134/S0021364007060082 | ||||
Tags | EXPRESSION | ||||
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Funding (1)
1 | European Commission | 505868 FP6-2002-NMP-1 STREP NANOCUES |
Abstract:
The positive feedback between messenger ribonucleic acid (mRNA) and regulatory-protein production may result in bistability and stochastic “bursts” in gene transcription. The temporal kinetics of such bursts has already been simulated in detail. We (i) show that the applicability of the temporal models may be limited due to relatively slow mRNA and/or protein diffusion and (ii) present the first 3D Monte-Carlo simulations indicating that, with explicit mRNA diffusion, the bursts may be much more irregular; the periods between bursts may be much shorter; and, depending on the circumstances, the burst window may be reduced or extended.
Cite:
Zhdanov V.P.
Effect of mRNA Diffusion on Stochastic Bursts in Gene Transcription
Journal of Experimental and Theoretical Physics Letters (JETP Letters). 2007. V.85. N6. P.302-305. DOI: 10.1134/S0021364007060082 WOS Scopus РИНЦ
Effect of mRNA Diffusion on Stochastic Bursts in Gene Transcription
Journal of Experimental and Theoretical Physics Letters (JETP Letters). 2007. V.85. N6. P.302-305. DOI: 10.1134/S0021364007060082 WOS Scopus РИНЦ
Original:
Zhdanov V.P.
The Effect of mRNA Diffusion on Stochastic Bursts in Gene Transcription
Письма в Журнал экспериментальной и теоретической физики. 2007. V.85. N6. P.360-364. RSCI РИНЦ
The Effect of mRNA Diffusion on Stochastic Bursts in Gene Transcription
Письма в Журнал экспериментальной и теоретической физики. 2007. V.85. N6. P.360-364. RSCI РИНЦ
Dates:
Submitted: | Feb 13, 2007 |
Published print: | Mar 25, 2007 |
Identifiers:
Web of science | WOS:000246725500008 |
Scopus | 2-s2.0-34249683166 |
Elibrary | 13546986 |
Chemical Abstracts | 2007:580117 |
Chemical Abstracts (print) | 147:251579 |
OpenAlex | W2048149084 |