Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs Full article
Journal |
Journal of Experimental and Theoretical Physics Letters (JETP Letters)
ISSN: 0021-3640 , E-ISSN: 1090-6487 |
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Output data | Year: 2008, Volume: 88, Number: 7, Pages: 466-469 Pages count : 4 DOI: 10.1134/S0021364008190120 | ||||
Tags | NONCODING RNAS; TRANSCRIPTION; REGULATORS; DYNAMICS; PROTEIN | ||||
Authors |
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Affiliations |
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Funding (1)
1 | Swedish Research Council |
Abstract:
In eukaryotic cells, the kinetics of gene expression depends on the interplay of messenger RNAs (mRNAs), proteins, and nonprotein coding RNAs, or, more specifically, microRNAs. Some microRNAs may target hundreds of mRNAs. To describe this case, the author proposes a kinetic model implying that the microRNA synthesis is suppressed by the protein produced via the translation of one of the target mRNAs. With physically reasonable model parameters, the model predicts bistability or, in other words, switches in the expression of hundreds of genes.
Cite:
Zhdanov V.P.
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Journal of Experimental and Theoretical Physics Letters (JETP Letters). 2008. V.88. N7. P.466-469. DOI: 10.1134/S0021364008190120 WOS Scopus РИНЦ
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Journal of Experimental and Theoretical Physics Letters (JETP Letters). 2008. V.88. N7. P.466-469. DOI: 10.1134/S0021364008190120 WOS Scopus РИНЦ
Original:
Zhdanov V.P.
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Письма в Журнал экспериментальной и теоретической физики. 2008. V.88. N7. P.539-542. RSCI РИНЦ
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Письма в Журнал экспериментальной и теоретической физики. 2008. V.88. N7. P.539-542. RSCI РИНЦ
Dates:
Submitted: | Jul 21, 2008 |
Published print: | Dec 1, 2008 |
Published online: | Dec 17, 2008 |
Identifiers:
Web of science | WOS:000261789700012 |
Scopus | 2-s2.0-57849104532 |
Elibrary | 13584549 |
Chemical Abstracts | 2008:1513886 |
Chemical Abstracts (print) | 150:231053 |
OpenAlex | W2075366669 |