Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System Full article
Journal |
Journal of Thermal Analysis and Calorimetry
ISSN: 1388-6150 , E-ISSN: 1572-8943 |
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Output data | Year: 2017, Volume: 127, Number: 2, Pages: 1593-1604 Pages count : 12 DOI: 10.1007/s10973-016-6003-8 | ||||||||||||
Tags | Cryotemperature SEM, DSC, Freeze-drying, Phase diagram, X-ray diffraction | ||||||||||||
Authors |
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Affiliations |
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Funding (4)
1 | Council for Grants of the President of the Russian Federation | СП-1144.2013.4 |
2 | Council for Grants of the President of the Russian Federation | СП-680.2013.4 |
3 | Federal Agency for Scientific Organizations | 0301-2014-0002 |
4 | Federal Agency for Scientific Organizations | 0330-2016-0004 (АААА-А17-117122790027-1) |
Abstract:
Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.
Cite:
Ogienko A.G.
, Drebushchak V.A.
, Bogdanova E.G.
, Yunoshev A.S.
, Ogienko A.A.
, Boldyreva E.V.
, Manakov A.Y.
Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System
Journal of Thermal Analysis and Calorimetry. 2017. V.127. N2. P.1593-1604. DOI: 10.1007/s10973-016-6003-8 WOS Scopus РИНЦ
Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System
Journal of Thermal Analysis and Calorimetry. 2017. V.127. N2. P.1593-1604. DOI: 10.1007/s10973-016-6003-8 WOS Scopus РИНЦ
Dates:
Submitted: | Jun 23, 2016 |
Accepted: | Nov 25, 2016 |
Published online: | Dec 19, 2016 |
Published print: | Feb 1, 2017 |
Identifiers:
Web of science | WOS:000394142200045 |
Scopus | 2-s2.0-85006486804 |
Elibrary | 29466588 |
Chemical Abstracts | 2016:2132412 |
OpenAlex | W2563395680 |