Application of Physical Methods of Pharmacy to Improve the Properties of Dosage Forms Full article
Journal |
Theoretical Foundations of Chemical Engineering
ISSN: 0040-5795 , E-ISSN: 1608-3431 |
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Output data | Year: 2014, Volume: 48, Number: 5, Pages: 722-732 Pages count : 11 DOI: 10.1134/S0040579514050133 | ||||||||||||
Tags | micronization sublimation drying paracetamol ibuprofen direct compression dynamics of dissolution salbutamol glycine lactose inhalation powders inhalation therapy | ||||||||||||
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Abstract:
It has been shown on the examples of paracetamol, ibuprofen, and salbutamol that the use of mixed water-organic solvents, which are capable of clathrate formation, enables one to obtain high-disperse drug powders that are weakly soluble in water via sublimation drying of frozen solutions. The prepared powders are applicable for direct compression to pellets, have a higher rate of passing into solution for drug compared to initial substances, and can be used to prepare the suspensions for children’s preparations and dosage forms as freon-free aerosols for pulmonary administration.
Cite:
Zevak E.G.
, Ogienko A.G.
, Myz' S.A.
, Yunoshev A.S.
, Kolesov B.A.
, Ogienko A.A.
, Achkasov A.F.
, Il'dyakov A.V.
, Shinkorenko M.P.
, Krasnikov A.A.
, Kuchumov B.M.
, Ancharov A.I.
, Manakov A.Y.
, Boldyreva E.V.
Application of Physical Methods of Pharmacy to Improve the Properties of Dosage Forms
Theoretical Foundations of Chemical Engineering. 2014. V.48. N5. P.722-732. DOI: 10.1134/S0040579514050133 WOS Scopus РИНЦ
Application of Physical Methods of Pharmacy to Improve the Properties of Dosage Forms
Theoretical Foundations of Chemical Engineering. 2014. V.48. N5. P.722-732. DOI: 10.1134/S0040579514050133 WOS Scopus РИНЦ
Original:
Зевак Е.Г.
, Огиенко А.Г.
, Мызь С.А.
, Юношев А.С.
, Колесов Б.А.
, Огиенко А.А.
, Ачкасов А.Ф.
, Ильдяков А.В.
, Шинкоренко М.П.
, Красников А.А.
, Кучумов Б.М.
, Анчаров А.И.
, Манаков А.Ю.
, Болдырева Е.В.
Применение физических методов фармации для улучшения свойств лекарственных форм
Химическая технология. 2013. Т.14. №8. С.480-491. РИНЦ
Применение физических методов фармации для улучшения свойств лекарственных форм
Химическая технология. 2013. Т.14. №8. С.480-491. РИНЦ
Dates:
Submitted: | Dec 14, 2012 |
Published print: | Sep 1, 2014 |
Published online: | Oct 12, 2014 |
Identifiers:
Web of science | WOS:000343836400024 |
Scopus | 2-s2.0-84909993929 |
Elibrary | 24001878 |
Chemical Abstracts | 2014:1753857 |
Chemical Abstracts (print) | 164:257100 |
OpenAlex | W2066524363 |