Localized mRNA Translation and Protein Association Review
Journal |
Central European Journal of Physics
ISSN: 1895-1082 , E-ISSN: 1644-3608 |
||||
---|---|---|---|---|---|
Output data | Year: 2014, Volume: 12, Number: 8, Pages: 603-609 Pages count : 7 DOI: 10.2478/s11534-014-0486-3 | ||||
Tags | association and degradation, gene transcription, mRNA translation, protein diffusion, subcellular processes | ||||
Authors |
|
||||
Affiliations |
|
Abstract:
Recent direct observations of localization of mRNAs and proteins both in prokaryotic and eukaryotic cells can be related to slowdown of diffusion of these species due to macromolecular crowding and their ability to aggregate and form immobile or slowly mobile complexes. Here, a generic kinetic model describing both these factors is presented and comprehensively analyzed. Although the model is non-linear, an accurate self-consistent analytical solution of the corresponding reaction-diffusion equation has been constructed, the types of localized protein distributions have been explicitly shown, and the predicted kinetic regimes of gene expression have been classified.
Cite:
Zhdanov V.P.
Localized mRNA Translation and Protein Association
Central European Journal of Physics. 2014. V.12. N8. P.603-609. DOI: 10.2478/s11534-014-0486-3 WOS Scopus РИНЦ
Localized mRNA Translation and Protein Association
Central European Journal of Physics. 2014. V.12. N8. P.603-609. DOI: 10.2478/s11534-014-0486-3 WOS Scopus РИНЦ
Dates:
Submitted: | Dec 14, 2013 |
Accepted: | May 14, 2014 |
Published online: | Jul 20, 2014 |
Published print: | Aug 1, 2014 |
Identifiers:
Web of science | WOS:000339798700010 |
Scopus | 2-s2.0-84904548874 |
Elibrary | 23967749 |
Chemical Abstracts | 2014:1185049 |
Chemical Abstracts (print) | 162:101699 |
OpenAlex | W2048199601 |