Control of Tissue Growth by Locally Produced Activator: Liver Regeneration Full article
Journal |
Physica A: Statistical Mechanics and its Applications
ISSN: 0378-4371 |
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Output data | Year: 2015, Volume: 421, Pages: 279-285 Pages count : 7 DOI: 10.1016/j.physa.2014.11.041 | ||||
Tags | Biological kinetics, Cell proliferation, Extracellular diffusion, Growth factors, Liver regeneration | ||||
Authors |
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Affiliations |
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Funding (1)
1 | Swedish Research Council |
Abstract:
In general, the tissue development is controlled by growth factors and depends on the biomechanics of cells. The corresponding kinetic models are focused primarily on the early stages of the development. The attempts to construct such models for the later stages are still rare. One of the notable examples here is liver regeneration. Referring to this process, the author proposes and analyzes a generic kinetic model describing the regulation of tissue growth by locally produced activator. The model includes activator diffusion and control of the rate of cell proliferation which is described by using the Hill expression. Although this control may be moderately or strongly non-linear, the qualitative changes in the regeneration kinetics are predicted to be modest. For moderately non-linear control, the evolution of the tissue volume to the steady-state value exhibits an initial relatively short linear stage and then becomes slightly slower so that the whole kinetics is close to exponential. For strongly non-linear control, the linear stage dominates and/or the kinetics may exhibit a S-like shape feature which is, however, rather weak. The identification of such qualitative features in experimentally measured kinetics is shown to be difficult, because the error bars in the experiments are typically too large.
Cite:
Zhdanov V.P.
Control of Tissue Growth by Locally Produced Activator: Liver Regeneration
Physica A: Statistical Mechanics and its Applications. 2015. V.421. P.279-285. DOI: 10.1016/j.physa.2014.11.041 WOS Scopus РИНЦ
Control of Tissue Growth by Locally Produced Activator: Liver Regeneration
Physica A: Statistical Mechanics and its Applications. 2015. V.421. P.279-285. DOI: 10.1016/j.physa.2014.11.041 WOS Scopus РИНЦ
Dates:
Submitted: | Apr 22, 2014 |
Published online: | Nov 24, 2014 |
Published print: | Mar 1, 2015 |
Identifiers:
Web of science | WOS:000348688200026 |
Scopus | 2-s2.0-84916620673 |
Elibrary | 23958877 |
OpenAlex | W2001485699 |