Abstract: Results of X-ray diffraction and IR-specroscopy studies of the role of hydrogen bonds in the structural distortion of the monoclinic and the orthorhombic polymorphs of paracetamol induced by hydrostatic pressure (up to 4-5 GPa) are analyzed. Two groups of phenomena were studied: (i) the anisotropic structural distortion of the same polymorph, (ii) transitions between the polymorphs induced by pressure. The bulk compressibilities of the two polymorphs are practically equal. The anisotropy of pressure-induced structural distortion is qualitatively different. Lattice expansion in particular crystallographic directions was observed for the monoclinic polymorph. With increasing pressure the intermolecular NH...O and OH...O hydrogen bonds contracted and the intramolecular angles between the planes of the phenyl ring and the acetamide group decreased. Pressure-induced transitions between the polymorphs were poorly reproducible and limited by nucleation of the new polymorph.

Cite: Boldyreva E.V. , Shakhtshneider T.P. , Ahsbahs H. , Uchtmann H. , Burgina E.B. , Baltakhinov V.P.
The Role of Hydrogen Bonds in the Pressure-Induced Structural Distortion of 4-Hydroxyacetanilide Crystals
Polish Journal of Chemistry. 2002. V.76. N9. P.1333-1346. WOS Scopus РИНЦ ANCAN

Dates:

Submitted:	Nov 29, 2001
Published print:	Sep 1, 2002

Identifiers:

Web of science:	WOS:000177392200016
Scopus:	2-s2.0-0036712332
Elibrary:	13400691
Chemical Abstracts:	2002:674627
Chemical Abstracts (print):	137:384473

Citing:

DB	Citing
Web of science	29
Scopus	29
Elibrary	30