Friedel-Crafts Alkylation of Benzene with α,β-Unsaturated Amides Full article
| Journal |
Tetrahedron Letters
ISSN: 0040-4039 |
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| Output data | Year: 2004, Volume: 45, Number: 18, Pages: 3547-3549 Pages count : 3 DOI: 10.1016/j.tetlet.2004.03.067 | ||
| Tags | Alkylation, Aluminum chloride, Amide, Friedel-Crafts, Superelectrophile | ||
| Authors |
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| Affiliations |
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Funding (2)
| 1 | University of Southern California | |
| 2 | French National Centre for Scientific Research |
Abstract:
A variety of α,β-unsaturated amides (RHCCH2CONR′2, R=H, Me, Ar; R′=H or Et) readily condense with benzene at room temperature in the presence of an excess of aluminum chloride to give the corresponding 3-phenylpropionamides in excellent yields. This simple, one-pot procedure proved to be efficient and very clean. The mechanism of these and related reactions is discussed and the participation of superelectrophilic dicationic intermediates is suggested.
Cite:
Koltunov K.Y.
, Walspurger S.
, Sommer J.
Friedel-Crafts Alkylation of Benzene with α,β-Unsaturated Amides
Tetrahedron Letters. 2004. V.45. N18. P.3547-3549. DOI: 10.1016/j.tetlet.2004.03.067 WOS Scopus РИНЦ ANCAN OpenAlex
Friedel-Crafts Alkylation of Benzene with α,β-Unsaturated Amides
Tetrahedron Letters. 2004. V.45. N18. P.3547-3549. DOI: 10.1016/j.tetlet.2004.03.067 WOS Scopus РИНЦ ANCAN OpenAlex
Dates:
| Submitted: | Feb 18, 2004 |
| Accepted: | Mar 12, 2004 |
| Published online: | Apr 1, 2004 |
| Published print: | Apr 26, 2004 |
Identifiers:
| Web of science: | WOS:000221022500002 |
| Scopus: | 2-s2.0-1842737315 |
| Elibrary: | 14364152 |
| Chemical Abstracts: | 2004:304090 |
| Chemical Abstracts (print): | 141:54036 |
| OpenAlex: | W2150154479 |