Abstract: In the past two decades, chiral sulfoxides have been finding increasing use, reflecting growing interest both in convenient auxiliaries in asymmetric synthesis and products with biological properties containing a chiral sulfinyl group. In 1984, groups of Kagan and Modena discovered that titanium(IV) isopropoxide - diethyltartrate based systems (also known as “modified Katsuki-Sharpless reagents”) are capable of asymmetric oxidizing of prochiral sulfides by alkylhydroperoxides. Later, catalytic versions of the titanium tartrate systems were developed (with up to 90 % yield and 90 % ee for certain sulfides) that remain the most applied systems for asymmetric sulfoxidations. However, the low turnover numbers (5-20), complexity and expensiveness of such systems stimulated the search for other transition metal based catalytic systems. This review will cover the progress in transition metal catalyzed asymmetric sulfides oxidations achieved since the discoveries of early 1980s to the present days.

Cite: Bryliakov K.P. , Talsi E.P.
Transition Metal Catalyzed Asymmetric Oxidation of Sulfides
Current Organic Chemistry. 2008. V.12. N5. P.386-404. DOI: 10.2174/138527208783743660 WOS Scopus РИНЦ ANCAN OpenAlex

Dates:

Published print:

Mar 1, 2008

Identifiers:

Web of science:	WOS:000254038500004
Scopus:	2-s2.0-42049121685
Elibrary:	13588820
Chemical Abstracts:	2008:748065
Chemical Abstracts (print):	149:513709
OpenAlex:	W2951561770

Citing:

DB	Citing
Web of science	40
Scopus	44
Elibrary	43
OpenAlex	43

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