Stochastic Model of the Formation of Cancer Metastases via Cancer Stem Cells Full article
| Journal |
European Biophysics Journal with Biophysics Letters
ISSN: 0175-7571 , E-ISSN: 1432-1017 |
||||
|---|---|---|---|---|---|
| Output data | Year: 2008, Volume: 37, Number: 8, Pages: 1329-1334 Pages count : 6 DOI: 10.1007/s00249-008-0341-9 | ||||
| Tags | Cancer, Cancer stem and progenitor cells, Mean-field kinetic equations, Metastases, Monte Carlo simulations, Premetastatic niches, Proliferation, differentiation and death of cells | ||||
| Authors |
|
||||
| Affiliations |
|
Funding (1)
| 1 | Chalmers University of Technology |
Abstract:
The author presents Monte Carlo simulations of the temporal kinetics of the formation of cancer metastases
with emphasis on cancer stem cells. The model used implies the existence of premetastatic niches. The population
of cancer stem cells located outside tumors and inducing the formation of new tumors in niches is considered
to be heterogeneous. If the niches are equivalent with respect to the formation of metastases, the kinetics are
predicted to exhibit an induction period and then rapid growth of the number of metastases. If the niches are
heterogeneous, the kinetics are found to be more gradual.
Cite:
Zhdanov V.P.
Stochastic Model of the Formation of Cancer Metastases via Cancer Stem Cells
European Biophysics Journal with Biophysics Letters. 2008. V.37. N8. P.1329-1334. DOI: 10.1007/s00249-008-0341-9 WOS Scopus РИНЦ OpenAlex
Stochastic Model of the Formation of Cancer Metastases via Cancer Stem Cells
European Biophysics Journal with Biophysics Letters. 2008. V.37. N8. P.1329-1334. DOI: 10.1007/s00249-008-0341-9 WOS Scopus РИНЦ OpenAlex
Dates:
| Submitted: | Dec 8, 2007 |
| Accepted: | Apr 17, 2008 |
| Published online: | May 8, 2008 |
| Published print: | Oct 1, 2008 |
Identifiers:
| Web of science: | WOS:000259247200006 |
| Scopus: | 2-s2.0-51849111910 |
| Elibrary: | 13572183 |
| OpenAlex: | W2005190572 |