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Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate Full article

Journal RSC Advances
ISSN: 2046-2069
Output data Year: 2016, Volume: 6, Number: 74, Pages: 69728-69732 Pages count : 5 DOI: 10.1039/C6RA15808K
Tags Ethyl acetates; Hyperpolarization; Hyperpolarized; Induced polarization; Magnetic field cycling; Natural abundance; Supported rhodium nanoparticles; Vinyl acetates
Authors Kovtunov K.V. 1,2 , Barskiy D.A. 3 , Salnikov O.G. 1,2 , Shchepin R. 3 , Coffey A.M. 3 , Kovtunova L.M. 2,4 , Bukhtiyarov V.I. 2,4 , Koptyug I.V. 1,2 , Chekmenev E.Y. 3,5
Affiliations
1 Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia
2 Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia
3 Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA
4 Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia
5 Russian Academy of Sciences, Leninskiy Prospect 14, 119991 Moscow, Russia

Funding (8)

1 Russian Science Foundation 14-23-00146
2 Federal Agency for Scientific Organizations 0333-2014-0001 (V.44.1.1)
3 Russian Science Foundation 14-13-00445
4 National Institutes of Health 1R21EB018014
5 National Institutes of Health 1R21EB020323
6 National Science Foundation CHE-1416268
7 United States Department of Defense W81XWH-12-1-0159/BC112431
8 United States Department of Defense W81XWH-15-1-0271

Abstract: Here, we report the production of 13C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of 13C isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.
Cite: Kovtunov K.V. , Barskiy D.A. , Salnikov O.G. , Shchepin R. , Coffey A.M. , Kovtunova L.M. , Bukhtiyarov V.I. , Koptyug I.V. , Chekmenev E.Y.
Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate
RSC Advances. 2016. V.6. N74. P.69728-69732. DOI: 10.1039/C6RA15808K WOS Scopus РИНЦ AN PMID OpenAlex
Files: Full text from publisher
Dates:
Submitted: Jun 17, 2016
Accepted: Jul 14, 2016
Published online: Jul 15, 2016
Identifiers:
Web of science: WOS:000381512800009
Scopus: 2-s2.0-84979984807
Elibrary: 27119694
Chemical Abstracts: 2016:1176504
PMID: 28042472
OpenAlex: W2462171873
Citing:
DB Citing
Web of science 26
Scopus 26
Elibrary 28
OpenAlex 29
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