Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate | Sciact - CRIS-system of Boreskov Institute of Catalysis

Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate Full article

Journal

RSC Advances
ISSN: 2046-2069

Output data

Year: 2016, Volume: 6, Number: 74, Pages: 69728-69732 Pages count : 5 DOI: 10.1039/C6RA15808K

Tags

Ethyl acetates; Hyperpolarization; Hyperpolarized; Induced polarization; Magnetic field cycling; Natural abundance; Supported rhodium nanoparticles; Vinyl acetates

Authors

Kovtunov K.V. ^1,2 , Barskiy D.A. ³ , Salnikov O.G. ^1,2 , Shchepin R. ³ , Coffey A.M. ³ , Kovtunova L.M. ^2,4 , Bukhtiyarov V.I. ^2,4 , Koptyug I.V. ^1,2 , Chekmenev E.Y. ^3,5

Affiliations

1	Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia
2	Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia
3	Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA
4	Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia
5	Russian Academy of Sciences, Leninskiy Prospect 14, 119991 Moscow, Russia

Funding (8)

1	Russian Science Foundation	14-23-00146
2	Russian Science Foundation	14-13-00445
3	Federal Agency for Scientific Organizations	0333-2014-0001 (V.44.1.1)
4	National Institutes of Health	1R21EB018014
5	National Institutes of Health	1R21EB020323
6	National Science Foundation	CHE-1416268
7	United States Department of Defense	W81XWH-12-1-0159/BC112431
8	United States Department of Defense	W81XWH-15-1-0271

Here, we report the production of 13C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of 13C isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.

Kovtunov K.V. , Barskiy D.A. , Salnikov O.G. , Shchepin R. , Coffey A.M. , Kovtunova L.M. , Bukhtiyarov V.I. , Koptyug I.V. , Chekmenev E.Y.
Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate

RSC Advances. 2016. V.6. N74. P.69728-69732. DOI: 10.1039/C6RA15808K WOS Scopus РИНЦ AN PMID OpenAlex

Full text from publisher

Submitted:	Jun 17, 2016
Accepted:	Jul 14, 2016
Published online:	Jul 15, 2016

Web of science:	WOS:000381512800009
Scopus:	2-s2.0-84979984807
Elibrary:	27119694
Chemical Abstracts:	2016:1176504
PMID:	28042472
OpenAlex:	W2462171873

DB	Citing
Web of science	26
Scopus	26
Elibrary	28
OpenAlex	30