Synthesis of Nanoscale TiO2 and Study of the Effect of Their Crystal Structure on Single Cell Response | Sciact - CRIS-система Института катализа

Synthesis of Nanoscale TiO2 and Study of the Effect of Their Crystal Structure on Single Cell Response Научная публикация

Журнал

The Scientific World Journal [electronic resource]
ISSN: 2356-6140 , E-ISSN: 1537-744X

Вых. Данные

Год: 2012, Том: 2012, Номер статьи : 498345, Страниц : 14 DOI: 10.1100/2012/498345

Ключевые слова

TITANIUM-DIOXIDE NANOPARTICLES; IN-VITRO; PULMONARY RESPONSE; PARTICLES; TOXICITY; NANOMATERIALS; RATS; STABILIZATION; CYTOTOXICITY; DISPERSION

Авторы

Ismagilov Z.R. ¹ , Shikina N.V. ¹ , Mazurkova N.A. ² , Tsikoza L.T. ¹ , Tuzikov F.V. ¹ , Ushakov V.A. ¹ , Ishchenko A.V. ¹ , Rudina N.A. ¹ , Korneev D.V. ² , Ryabchikova E.I. ³

Организации

1	Boreskov Institute of Catalysis, Siberian Branch of RAS, 5, Pr. Akad. Lavrentieva, Novosibirsk 630090, Russia
2	The Vector State Research Center of Virology and Biotechnology, Rospotrebnadzor, Korp. 12, Novosibirsk oblast, Koltsovo 630559, Russia
3	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of RAS, 8, Pr. Akad. Lavrentieva, Novosibirsk 630090, Russia

Информация о финансировании (4)

1	Российский фонд фундаментальных исследований	11-04-01408 (01201158854)
2	Министерство образования и науки Российской Федерации	16.512.11.2267 (01201176480)
3	Министерство образования и науки Российской Федерации	2.1.1/5642
4	Сибирское отделение Российской академии наук	61

To study the effect of nanoscale titanium dioxide (TiO2) on cell responses, we synthesized four modifications of the TiO2 (amorphous, anatase, brookite, and rutile) capable of keeping their physicochemical characteristics in a cell culture medium. The modifications of nanoscale TiO2 were obtained by hydrolysis of TiCl4 and Ti(i-OC3H7)4 (TIP) upon variation of the synthesis conditions; their textural, morphological, structural, and dispersion characteristics were examined by a set of physicochemical methods: XRD, BET, SAXS, DLS, AFM, SEM, and HR-TEM. The effect of synthesis conditions (nature of precursor, pH, temperature, and addition of a complexing agent) on the structural-dispersion properties of TiO2 nanoparticles was studied. The hydrolysis methods providing the preparation of amorphous, anatase, brookite, and rutile modifications of TiO2 nanoparticles 3–5 nm in size were selected. Examination of different forms of TiO2 nanoparticles interaction with MDCK cells by transmission electron microscopy of ultrathin sections revealed different cell responses after treatment with different crystalline modifications and amorphous formof TiO2. The obtained results allowed us to conclude that direct contact of the nanoparticles with cell plasma membrane is the primary and critical step of their interaction and defines a subsequent response of the cell.

Ismagilov Z.R. , Shikina N.V. , Mazurkova N.A. , Tsikoza L.T. , Tuzikov F.V. , Ushakov V.A. , Ishchenko A.V. , Rudina N.A. , Korneev D.V. , Ryabchikova E.I.
Synthesis of Nanoscale TiO2 and Study of the Effect of Their Crystal Structure on Single Cell Response

The Scientific World Journal [electronic resource]. 2012. V.2012. 498345 :1-14. DOI: 10.1100/2012/498345 WOS Scopus РИНЦ OpenAlex CAPlusCA PMID

Полный текст от издателя

Поступила в редакцию:	31 окт. 2011 г.
Принята к публикации:	15 дек. 2011 г.

≡ Web of science:	WOS:000305432500001
≡ Scopus:	2-s2.0-84862333721
≡ РИНЦ:	17991894
≡ OpenAlex:	W1998730824
≡ Chemical Abstracts:	2012:1390144
≡ Chemical Abstracts (print):	160:381812
≡ PMID (PubMed):	22623903

≡ Web of science	18	Сбор данных от 20.02.2026
≡ Scopus	21	Сбор данных от 22.02.2026
≡ РИНЦ	26	Сбор данных от 22.02.2026
≡ OpenAlex	20	Сбор данных от 22.02.2026