Production of Pure Aqueous 13C-Hyperpolarized Acetate Via Heterogeneous Parahydrogen-Induced Polarization | Sciact - CRIS-system of Boreskov Institute of Catalysis

Production of Pure Aqueous 13C-Hyperpolarized Acetate Via Heterogeneous Parahydrogen-Induced Polarization Full article

Journal

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Output data

Year: 2016, Volume: 22, Number: 46, Pages: 16446-16449 Pages count : 5 DOI: 10.1002/chem.201603974

Tags

13C NMR, hyperpolarization, parahydrogen, PHIP, polarization transfer

Authors

Kovtunov Kirill V. ^1,2 , Barskiy Danila A. ^3,4,5 , Shchepin Roman V. ^3,4,5 , Salnikov Oleg G. ^1,2 , Prosvirin Igor P. ^2,6 , Bukhtiyarov Andrey V. ^2,6 , Kovtunova Larisa M. ^2,6 , Bukhtiyarov Valerii I. ^2,6 , Koptyug Igor V. ^1,2 , Chekmenev Eduard Y. ^3,4,5,7

Affiliations

1	Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
2	Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090 (Russia)
3	Department of Radiology, Vanderbilt University, Institute of Imaging Science (VUIIS), Nashville, Tennessee, 37232-2310 (USA)
4	Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, 37232-2310 (USA)
5	Department of Physics and Astronomy, Nashville, Tennessee, 37232-2310 (USA)
6	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090 (Russia)
7	Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow (Russia)

Funding (13)

1	Russian Science Foundation	14-23-00146
2	Federal Agency for Scientific Organizations	0303-2015-0010
3	Federal Agency for Scientific Organizations	0333-2014-0001 (V.44.1.1)
4	Russian Foundation for Basic Research	14-03-93183
5	The Ministry of Education and Science of the Russian Federation	МК-4498.2016.3
6	Russian Science Foundation	14-13-00445
7	National Institutes of Health	1R21EB018014
8	National Institutes of Health	1R21EB020323
9	National Science Foundation	CHE-1416268
10	United States Department of Defense	W81XWH-12-1-0159/BC112431
11	United States Department of Defense	W81XWH-15-1-0271
12	National Science Foundation	CHE-1416432
13	ExxonMobil

A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce 13C-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO2 catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized 13C-enriched ethyl acetate-1-13C detected at 9.4 T. An approximately 14-fold 13C signal enhancement was detected using 50 % parahydrogen without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to 13C nuclei. This first observation of 13C PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.

Kovtunov K.V. , Barskiy D.A. , Shchepin R.V. , Salnikov O.G. , Prosvirin I.P. , Bukhtiyarov A.V. , Kovtunova L.M. , Bukhtiyarov V.I. , Koptyug I.V. , Chekmenev E.Y.
Production of Pure Aqueous 13C-Hyperpolarized Acetate Via Heterogeneous Parahydrogen-Induced Polarization

Chemistry - A European Journal. 2016. V.22. N46. P.16446-16449. DOI: 10.1002/chem.201603974 WOS Scopus РИНЦ ANCAN PMID OpenAlex

Full text from publisher

Submitted:	Aug 21, 2016
Published online:	Sep 8, 2016
Published print:	Nov 7, 2016

Web of science:	WOS:000387133600013
Scopus:	2-s2.0-84994013695
Elibrary:	27577965
Chemical Abstracts:	2016:1485713
Chemical Abstracts (print):	165:506968
PMID:	27607402
OpenAlex:	W2515756319

DB	Citing
Web of science	34
Scopus	34
Elibrary	33
OpenAlex	39