Abstract: When catalytic hydrogenations use parahydrogen instead of normal H2, the NMR signals of reaction products and intermediates can be dramatically enhanced. This phenomenon, called parahydrogen-induced polarization (PHIP), has been used previously to address the mechanisms of H2 activation by transition metal complexes and clusters in solution. At the same time, it is highly desirable to combine this methodology with heterogeneous catalysis. Potential benefits of such combination include the possibility to develop a hypersensitive NMR-based tool for mechanistic studies of heterogeneous catalytic processes as well as to establish an efficient technology for the production of novel contrast agents for in vivo MRI. To achieve this, one needs to combine the ‘homogeneous’ hydrogenation mechanism, which incorporates both H atoms of a H2 molecule into the same product molecule, with the ease of catalyst removal and the possibility to perform the reaction in a continuous mode, the inherent features of heterogeneous catalysis. This field of NMR and MRI research can thus benefit from the current efforts at the interface between homogeneous and heterogeneous catalysis. Here, after a brief introduction of the PHIP phenomenon, the current progress in combining PHIP with heterogeneous hydrogenations is discussed, and future promising directions are outlined.

Cite: Kovtunov K.V. , Salnikov O.G. , Zhivonitko V.V. , Skovpin I.V. , Bukhtiyarov V.I. , Koptyug I.V.
Catalysis and Nuclear Magnetic Resonance Signal Enhancement with Parahydrogen
Topics in Catalysis. 2016. V.59. N19. P.1686-1699. DOI: 10.1007/s11244-016-0688-6 WOS Scopus РИНЦ ANCAN OpenAlex

Dates:

Published online:	Aug 18, 2016
Published print:	Dec 1, 2016

Identifiers:

Web of science:	WOS:000388825800003
Scopus:	2-s2.0-84998787276
Elibrary:	27585638
Chemical Abstracts:	2016:1380767
Chemical Abstracts (print):	165:602894
OpenAlex:	W2512209628

Citing:

DB	Citing
Web of science	25
Scopus	25
Elibrary	24
OpenAlex	31

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