Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals | Sciact - CRIS-system of Boreskov Institute of Catalysis

Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals Full article

Journal

Angewandte Chemie - International Edition
ISSN: 1433-7851 , E-ISSN: 1521-3773

Output data

Year: 2017, Volume: 56, Number: 35, Pages: 10433-10437 Pages count : 5 DOI: 10.1002/anie.201705014

Tags

het-SABRE, heterogeneous catalysis, heteronuclei, hyperpolarization, parahydrogen

Authors

Kovtunov Kirill V. ^1,2 , Kovtunova Larisa M. ^2,3 , Gemeinhardt Max E. ⁴ , Bukhtiyarov Andrey V. ³ , Gesiorski Jonathan ⁴ , Bukhtiyarov Valerii I. ³ , Chekmenev Eduard Y. ^6,7,8,9 , Koptyug Igor V. ^1,2 , Goodson Boyd ^4,5

Affiliations

1	Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
2	Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090 (Russia)
3	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090 (Russia)
4	Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL 62901 (United States)
5	Materials Technology Center, Southern Illinois University, Carbondale, IL 62901 (United States)
6	Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Nashville, Tennessee, 37232-2310 (United States)
7	Department of Biomedical Engineering, VICC, Nashville, Tennessee, 37232-2310 (United States)
8	Department of Physics and Astronomy, Nashville, Tennessee, 37232-2310 (United States)
9	Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow (Russia)

Funding (13)

1	Russian Science Foundation	14-23-00146
2	Russian Foundation for Basic Research	16-03-00407
3	The Ministry of Education and Science of the Russian Federation	МК-4498.2016.3
4	National Institutes of Health	1R21EB018014
5	National Institutes of Health	1R21EB020323
6	National Science Foundation	CHE-1416268
7	United States Department of Defense	W81XWH-12-1-0159/BC112431
8	United States Department of Defense	W81XWH-15-1-0271
9	National Science Foundation	CHE-1416432
10	ExxonMobil
11	United States Department of Defense	W81XWH-15-1-0272
12	Federal Agency for Scientific Organizations	V.44.1.8. (0333-2016-0001)
13	Russian Foundation for Basic Research	17-54-33037

The hyperpolarization of heteronuclei via Signal Amplification by Reversible Exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes = 1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD = cyclooctadiene] catalyst onto silica particles modified with NH2(CH2)3- linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate ~102-fold enhancement of 15N NMR signals in pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XRD characterization, supports that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.

Kovtunov K.V. , Kovtunova L.M. , Gemeinhardt M.E. , Bukhtiyarov A.V. , Gesiorski J. , Bukhtiyarov V.I. , Chekmenev E.Y. , Koptyug I.V. , Goodson B.
Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals

Angewandte Chemie - International Edition. 2017. V.56. N35. P.10433-10437. DOI: 10.1002/anie.201705014 WOS Scopus РИНЦ AN PMID OpenAlex

Kovtunov K.V. , Kovtunova L.M. , Gemeinhardt M.E. , Bukhtiyarov A.V. , Gesiorski J. , Bukhtiyarov V.I. , Chekmenev E.Y. , Koptyug I.V. , Goodson B.M.
Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals

Angewandte Chemie (German edition). 2017. V.129. N35. P.10569-10573. DOI: 10.1002/ange.201705014 РИНЦ OpenAlex

Full text from publisher

Submitted:	May 15, 2017
Published online:	Jun 23, 2017
Published print:	Aug 21, 2017

Web of science:	WOS:000434546000026
Scopus:	2-s2.0-85026362064
Elibrary:	31111407
Chemical Abstracts:	2017:1250748
PMID:	28644918
OpenAlex:	W2672941940

DB	Citing
Web of science	55
Scopus	57
Elibrary	50
OpenAlex	66