Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells Full article
| Journal |
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 , E-ISSN: 1573-8221 |
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| Output data | Year: 2017, Volume: 163, Number: 4, Pages: 561-565 Pages count : 5 DOI: 10.1007/s10517-017-3849-0 | ||||||
| Tags | glioblastoma, manganese nanoparticles, MTT test, U-251, U-87MG | ||||||
| Authors |
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| Affiliations |
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Funding (2)
| 1 | Russian Science Foundation | 14-50-00080 |
| 2 | Russian Science Foundation | 14-14-00221 |
Abstract:
Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС50 for tumor cells. Five of 6 samples of tested nanoparticles demonstrated selective toxic effect in vitro. Manganese oxide nanoparticles were characterized by maximum selectivity (СС50 6.9 nM and 2.1 nM for U-87MG and U-251 cells, respectively): selectivity index for glioblastoma U-87MG and U-251 cells was 29 and 95.2, respectively. Manganese oxide nanoparticles used for MRI detection of gliomas can be used for designing an oncolytic agent for the treatment of glial tumors in humans.
Cite:
Razumov I.A.
, Zav’yalov E.L.
, Troitskii S.Y.
, Romashchenko A.V.
, Petrovskii D.V.
, Kuper K.E.
, Moshkin M.P.
Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells
Bulletin of Experimental Biology and Medicine. 2017. V.163. N4. P.561-565. DOI: 10.1007/s10517-017-3849-0 WOS Scopus РИНЦ AN PMID OpenAlex
Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells
Bulletin of Experimental Biology and Medicine. 2017. V.163. N4. P.561-565. DOI: 10.1007/s10517-017-3849-0 WOS Scopus РИНЦ AN PMID OpenAlex
Original:
Разумов И.А.
, Завьялов Е.Л.
, Троицкий С.Ю.
, Ромащенко А.В.
, Петровский Д.В.
, Купер К.Э.
, Мошкин М.П.
Избирательная цитотоксичность наночастиц марганца в отношении клеток глиобластом человека
Клеточные технологии в биологии и медицине. 2017. №2. С.114-118. РИНЦ
Избирательная цитотоксичность наночастиц марганца в отношении клеток глиобластом человека
Клеточные технологии в биологии и медицине. 2017. №2. С.114-118. РИНЦ
Dates:
| Submitted: | Dec 6, 2016 |
| Published print: | Aug 1, 2017 |
| Published online: | Aug 29, 2017 |
Identifiers:
| Web of science: | WOS:000409342400035 |
| Scopus: | 2-s2.0-85028768777 |
| Elibrary: | 31117618 |
| Chemical Abstracts: | 2017:1481442 |
| PMID: | 28853080 |
| OpenAlex: | W2752643534 |