Abstract: The ligand-receptor-mediated contacts of small sub-100-nm-sized lipid vesicles (or nanoparticles) with the cellular membrane are of interest in the contexts of cell-to-cell communication, endocytosis of membrane-coated virions, and drug (RNA) delivery. In all these cases, the interior of vesicles is filled by biologically relevant content. Despite the diversity of such systems, the corresponding ligand-receptor interaction possesses universal features. One of them is that the vesicle-membrane contacts can be accompanied by the redistribution of ligands and receptors between the contact and contact-free regions. In particular, the concentrations of ligands and receptors may become appreciably higher in the contact regions and their composition may there be different compared to that in the suspended state in the solution. A statistical model presented herein describes the corresponding distribution of various ligands and receptors and allows one to calculate the related change of the free energy with variation of the vesicle-engulfment extent. The results obtained are used to clarify the necessary conditions for the vesicle-assisted pathway of drug delivery.

Cite: Zhdanov V.P.
Multivalent Ligand-Receptor-Mediated Interaction of Small Filled Vesicles with a Cellular Membrane
Physical Review E. 2017. V.96. N1. 012408 :1-10. DOI: 10.1103/PhysRevE.96.012408 WOS Scopus РИНЦ ANCAN PMID OpenAlex

Files: Full text from publisher

Dates:

Submitted:	Mar 23, 2017
Accepted:	May 23, 2017
Published print:	Jul 1, 2017
Published online:	Jul 17, 2017

Identifiers:

Web of science:	WOS:000405713900011
Scopus:	2-s2.0-85026472154
Elibrary:	31111657
Chemical Abstracts:	2018:2178509
Chemical Abstracts (print):	170:36768
PMID:	29347247
OpenAlex:	W2735182363

Citing:

DB	Citing
Web of science	17
Scopus	18
Elibrary	16
OpenAlex	20

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