Abstract: mRNA delivery into cells forms the basis for one of the new and promising ways to treat various diseases. Among suitable carriers, lipid nanoparticles (LNPs) with a size of about 100 nm are now often employed. Despite high current interest in this area, the understanding of the basic details of LNP-mediated mRNA delivery and function is limited. To clarify the kinetics of mRNA release from LNPs, the author uses three generic models implying (i) exponential, (ii) diffusion-controlled, and (iii) detachment-controlled kinetic regimes, respectively. Despite the distinct differences in these kinetics, the associated transient kinetics of mRNA translation to the corresponding protein and its degradation are shown to be not too sensitive to the details of the mRNA delivery by LNPs (or other nanocarriers). In addition, the author illustrates how this protein may temporarily influence the expression of one gene or a few equivalent genes. The analysis includes positive or negative regulation of the gene transcription via the attachment of the protein without or with positive or negative feedback in the gene expression. Stable, bistable, and oscillatory schemes have been scrutinized in this context.

Cite: Zhdanov V.P.
Kinetics of Lipid-Nanoparticle-Mediated Intracellular mRNA Delivery and Function
Physical Review E. 2017. V.96. N4. 042406 :1-22. DOI: 10.1103/PhysRevE.96.042406 WOS Scopus РИНЦ ANCAN PMID OpenAlex

Dates:

Submitted:	Jun 24, 2017
Accepted:	Sep 3, 2017
Published print:	Oct 1, 2017
Published online:	Oct 10, 2017

Identifiers:

Web of science:	WOS:000412703500001
Scopus:	2-s2.0-85031028189
Elibrary:	31094857
Chemical Abstracts:	2018:2188103
Chemical Abstracts (print):	170:99697
PMID:	29347496
OpenAlex:	W2764223985

Citing:

DB	Citing
Web of science	17
Scopus	18
Elibrary	17
OpenAlex	19

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