Abstract: Nanocarrier-mediated mRNA delivery and release into the cells with subsequent translation to protein is of interest in the context of the development of a new generation of drugs. In particular, this protein can play a role of a transcription factor and be used as a tool to regulate temporarily the genetic networks. The corresponding transient kinetics of gene expression are expected to depend on the mechanism and duration of mRNA release. Assuming the release to be rapid on the time scale of other steps, the author shows theoretically the mRNA-related transient features of gene expression occurring in stable, bistable, and oscillatory regimes in a single cell. Qualitatively, the results obtained are found to be fairly similar to those reported earlier for the situation when the release is slow. Thus, the features of the transient kinetics under consideration appear to be less sensitive to the duration of mRNA release compared to what one might expect.

Cite: Zhdanov V.P.
mRNA Function After Intracellular Delivery and Release
Biosystems. 2018. V.165. P.52-56. DOI: 10.1016/j.biosystems.2018.01.003 WOS Scopus РИНЦ AN PMID OpenAlex

Dates:

Submitted:	Oct 21, 2017
Accepted:	Jan 8, 2018
Published online:	Jan 11, 2018
Published print:	Mar 1, 2018

Identifiers:

Web of science:	WOS:000428489100006
Scopus:	2-s2.0-85043306783
Elibrary:	35496867
Chemical Abstracts:	2018:259756
PMID:	29331630
OpenAlex:	W2783420088

Citing:

DB	Citing
Web of science	8
Scopus	8
Elibrary	8
OpenAlex	8

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