Inadvertent Liquid Assisted Grinding: A Key to Dry Organic Mechano-Co-crystallisation? | Sciact - CRIS-система Института катализа

Inadvertent Liquid Assisted Grinding: A Key to Dry Organic Mechano-Co-crystallisation? Научная публикация

Журнал

CrystEngComm
ISSN: 1466-8033

Вых. Данные

Год: 2017, Том: 19, Номер: 21, Страницы: 2830-2835 Страниц : 6 DOI: 10.1039/c7ce00517b

Ключевые слова

COCRYSTAL FORMATION; MOLECULAR-CRYSTALS; MECHANOCHEMISTRY; CAKING; POWDERS; TEMPERATURE

Авторы

Tumanov I.A. ^1,2 , Michalchuk A.A.L. ^1,3,4 , Politov A.A. ^1,2 , Boldyreva E.V. ² , Boldyrev V.V. ²

Организации

1	Novosibirsk State University, Novosibirsk, Russian Federation
2	Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Novosibirsk, Russian Federation
3	EaStChem School of Chemistry, University of Edinburgh, Edinburgh, United Kingdom
4	EPSRC Centre for Continuous Manufacturing and Crystallisation (CMAC), United Kingdom

Информация о финансировании (5)

1	Российский фонд фундаментальных исследований	16-33-60086 (АААА-А15-115121840103-1)
2	The University of Edinburgh
3	Engineering and Physical Sciences Research Council	CMAC 1/1033459/1
4	Федеральное агентство научных организаций России	0301-2016-0014 (АААА-А17-117030310274-5)
5	Министерство образования и науки Российской Федерации	1828

Mechanical treatment of dry powder mixtures has often been reported to give new compounds. The assumption of neat mechanochemical conditions must, however, be made with caution even if the reactants are not crystal hydrates. The fluidised intermediate, which is often necessary for mechano-cocrystallisation of organic molecules, can readily form by interaction with atmospheric moisture. We illustrate this using "dry" mechanochemical synthesis of glycinium semi-malonate as an example. The α-glycine and malonic acid mixture is shown to be highly hygroscopic, which can be largely accredited to the hygroscopicity of malonic acid. Dissolution in atmospheric moisture is sufficient for the spontaneous crystallisation of the salt product. This is a prime example where liquid is both necessary for mechanosynthesis, while simultaneously hindering the reaction by affecting the rheology of the mixture: Liquid Hindered Grinding. These results shed new light on possible sources of regional, seasonal and temperature effects on mechanosynthesis, as well as a potential role for polymer additives.

Tumanov I.A. , Michalchuk A.A.L. , Politov A.A. , Boldyreva E.V. , Boldyrev V.V.
Inadvertent Liquid Assisted Grinding: A Key to Dry Organic Mechano-Co-crystallisation?

CrystEngComm. 2017. V.19. N21. P.2830-2835. DOI: 10.1039/c7ce00517b WOS Scopus РИНЦ CAPlus OpenAlex

Полный текст от издателя

Поступила в редакцию:	16 мар. 2017 г.
Принята к публикации:	3 мая 2017 г.
Опубликована online:	3 мая 2017 г.
Опубликована в печати:	7 июн. 2017 г.

Web of science:	WOS:000402545700001
Scopus:	2-s2.0-85029602649
РИНЦ:	31054506
Chemical Abstracts:	2017:700618
OpenAlex:	W2610199434

БД	Цитирований
Web of science	40
Scopus	44
OpenAlex	47