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Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System Научная публикация

Журнал Journal of Thermal Analysis and Calorimetry
ISSN: 1388-6150 , E-ISSN: 1572-8943
Вых. Данные Год: 2017, Том: 127, Номер: 2, Страницы: 1593-1604 Страниц : 12 DOI: 10.1007/s10973-016-6003-8
Ключевые слова Cryotemperature SEM, DSC, Freeze-drying, Phase diagram, X-ray diffraction
Авторы Ogienko A.G. 1,2 , Drebushchak V.A. 2,3 , Bogdanova E.G. 1,2 , Yunoshev A.S. 2,4 , Ogienko A.A. 5 , Boldyreva E.V. 6 , Manakov A.Y. 1,2
Организации
1 Nikolaev Institute of Inorganic Chemistry SB RAS, Lavrentiev Ave. 3, Novosibirsk, Russia 630090
2 Novosibirsk State University, ul. Pirogova 2, Novosibirsk, Russia 630090
3 Sobolev Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russia 630090
4 Lavrentiev Institute of Hydrodynamics SB RAS, Novosibirsk, Russia 630090
5 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 630090
6 Institute of Solid State Chemistry and Mechanochemistry SB RAS, ul. Kutateladze 18, Novosibirsk, Russia 630128

Информация о финансировании (4)

1 Совет по грантам Президента Российской Федерации СП-1144.2013.4
2 Совет по грантам Президента Российской Федерации СП-680.2013.4
3 Федеральное агентство научных организаций России 0301-2014-0002
4 Федеральное агентство научных организаций России 0330-2016-0004 (АААА-А17-117122790027-1)

Реферат: Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.
Библиографическая ссылка: Ogienko A.G. , Drebushchak V.A. , Bogdanova E.G. , Yunoshev A.S. , Ogienko A.A. , Boldyreva E.V. , Manakov A.Y.
Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System
Journal of Thermal Analysis and Calorimetry. 2017. V.127. N2. P.1593-1604. DOI: 10.1007/s10973-016-6003-8 WOS Scopus РИНЦ CAPlus OpenAlex
Даты:
Поступила в редакцию: 23 июн. 2016 г.
Принята к публикации: 25 нояб. 2016 г.
Опубликована online: 19 дек. 2016 г.
Опубликована в печати: 1 февр. 2017 г.
Идентификаторы БД:
Web of science: WOS:000394142200045
Scopus: 2-s2.0-85006486804
РИНЦ: 29466588
Chemical Abstracts: 2016:2132412
OpenAlex: W2563395680
Цитирование в БД:
БД Цитирований
Web of science 11
Scopus 12
OpenAlex 12
Альметрики: