Simple and Efficient Modifications of Well Known Techniques for Reliable Growth of High-Quality Crystals of Small Bioorganic Molecules | Sciact - CRIS-система Института катализа

Simple and Efficient Modifications of Well Known Techniques for Reliable Growth of High-Quality Crystals of Small Bioorganic Molecules Научная публикация

Журнал

Journal of Applied Crystallography
ISSN: 0021-8898 , E-ISSN: 1600-5767

Вых. Данные

Год: 2014, Том: 47, Номер: 4, Страницы: 1435-1442 Страниц : 8 DOI: 10.1107/S1600576714011273

Ключевые слова

crystal growth from solution; X-ray diffraction; Raman spectroscopy; control of nucleation; control of nuclei growth; seeding.

Авторы

Rychkov D.A. ^1,2 , Arkhipov S.G. ^1,2 , Boldyreva E.V. ^1,2

Организации

1	REC-008, Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russian Federation
2	Institute of Solid State Chemistry, Siberian Branch, Russian Academy of Sciences, Kutateladze 18, Novosibirsk 630128, Russian Federation

A number of modifications to traditional techniques are suggested in order to overcome problems that frequently arise when growing crystals from solution. These improvements, and their combination, help to avoid problems such as poor nucleation, the spontaneous precipitation of many poor-quality small powder-like crystals, crystals adhering to the crystallization vessel or to each other, and chemical degradation of the solution. The proposed techniques can be used to crystallize desirable metastable polymorphs reliably. None of the suggested methods demands the usage of any special or expensive equipment, or specific skills, and they can be implemented in the chemistry curriculum even at secondary school level. Examples are given for the crystallization of small organic molecules such as carboxylic acids, amino acids, pharmaceuticals etc., but the same techniques are applicable to other classes of compound.

Rychkov D.A. , Arkhipov S.G. , Boldyreva E.V.
Simple and Efficient Modifications of Well Known Techniques for Reliable Growth of High-Quality Crystals of Small Bioorganic Molecules

Journal of Applied Crystallography. 2014. V.47. N4. P.1435-1442. DOI: 10.1107/S1600576714011273 WOS Scopus РИНЦ CAPlusCA OpenAlex

Полный текст от издателя

Поступила в редакцию:	14 янв. 2014 г.
Принята к публикации:	15 мая 2014 г.
Опубликована online:	14 июн. 2014 г.
Опубликована в печати:	1 авг. 2014 г.

Web of science:	WOS:000340362000031
Scopus:	2-s2.0-84905454410
РИНЦ:	23977469
Chemical Abstracts:	2014:1261031
Chemical Abstracts (print):	163:265977
OpenAlex:	W2033470409

БД	Цитирований
Web of science	23
Scopus	24
OpenAlex	24