Intracellular miRNA or siRNA Delivery and Function Научная публикация
| Журнал |
Biosystems
ISSN: 0303-2647 , E-ISSN: 1872-8324 |
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| Вых. Данные | Год: 2018, Том: 171, Страницы: 20-25 Страниц : 6 DOI: 10.1016/j.biosystems.2018.05.007 | ||||
| Ключевые слова | Drug delivery; Subcellular processes; Gene expression; Mean-field kinetic equations | ||||
| Авторы |
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| Организации |
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Информация о финансировании (2)
| 1 | Федеральное агентство научных организаций России | 0303-2016-0001 |
| 2 | Stiftelsen för strategisk forskning | IRC15-0065 |
Реферат:
Nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into the cells with subsequent suppression of the populations of some of the mRNAs and proteins is of interest in the context of the development of a new generation of drugs. Bearing in mind such applications, the author shows the specifics of the corresponding transient kinetics by using three generic models without and with feedback resulting in bistability in the gene expression. In the absence of feedback, the suppression of the mRNA and protein population is transient. In the case of bistable kinetics, non-coding RNA can induce transition from the initial steady state to another steady state. The duration of this transition can be much longer than the time scale characterizing the drop of the non-coding RNA population. Quantitatively, the effect of the delivered non-coding RNA on gene expression can be appreciable if the maximum non-coding RNA population in the cytoplasm is comparable to or above 1000. All these conclusions have been drawn on the basis of calculations performed with the kinetic parameters typical for human cells.
Библиографическая ссылка:
Zhdanov V.P.
Intracellular miRNA or siRNA Delivery and Function
Biosystems. 2018. V.171. P.20-25. DOI: 10.1016/j.biosystems.2018.05.007 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Intracellular miRNA or siRNA Delivery and Function
Biosystems. 2018. V.171. P.20-25. DOI: 10.1016/j.biosystems.2018.05.007 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Даты:
| Поступила в редакцию: | 10 мар. 2018 г. |
| Принята к публикации: | 25 мая 2018 г. |
| Опубликована online: | 30 мая 2018 г. |
| Опубликована в печати: | 1 сент. 2018 г. |
Идентификаторы БД:
| Web of science: | WOS:000444356800003 |
| Scopus: | 2-s2.0-85049581868 |
| РИНЦ: | 35747895 |
| Chemical Abstracts: | 2018:1300471 |
| PMID (PubMed): | 29859208 |
| OpenAlex: | W2805114828 |