Synthesis and Crystal Structure of a Meloxicam Co-Crystal with Benzoic Acid | Sciact - CRIS-system of Boreskov Institute of Catalysis

Synthesis and Crystal Structure of a Meloxicam Co-Crystal with Benzoic Acid Full article

Journal

Structural Chemistry
ISSN: 1040-0400 , E-ISSN: 1572-9001

Output data

Year: 2018, Volume: 29, Number: 6, Pages: 1867–1874 Pages count : 5 DOI: 10.1007/s11224-018-1166-5

Tags

Oxicam . Meloxicam . Solubility . Benzoic acid . Co-crystal . Co-former . Aromatic . Carboxylic acid

Authors

Tantardini Christian ^1,2 , Arkipov Sergey G. ^2,3 , Cherkashina Kseniya A. ² , Kil’met’ev Alexander S. ^2,4 , Boldyreva Elena V. ^2,5

Affiliations

1	SkolTech Skolkovo Institute of Science and Technology, ul. Nobelya 3, Moscow, Russian Federation 121205
2	Novosibirsk State University, ul. Pirogova 2, Novosibirsk, Russian Federation 630090
3	Institute of Solid State Chemistry and Mechanochemistry SB RAS, ul. Kutateladze 18, Novosibirsk, Russian Federation 630128
4	Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentiev Ave. 9, Novosibirsk, Russian Federation 630090
5	Boreskov Institute of Catalysis SB RAS, Laverentiev Ave. 5, Novosibirsk, Russian Federation 630090

Funding (1)

Ministry of Science and Higher Education of the Russian Federation

Single crystals of a 1:1 c o-crystal of meloxicam [ 4-hydroxy-2-methyl-N-(5-me thyl-1,3-thiazol-2-yl)-1,1-dioxo-2H-1λ6,2-benzothiazine-3-carboxamide], MXM, with benzoic acid, BZA, were crystalized from a THF solution. The same MXM-BZAco-crystal has been obtained as a fine powder by liquid-assisted co-grinding using as fluid additives solvents with differentpolarity: benzene, toluene, ortho-xylene, meta-xylene, para-xylene, THF, and water. The latter is especially eco-friendly and canbe a good candidate for industrial production. The crystal structures of all the MXM co-crystals deposited in the most recentversion of the Cambridge Database were compared, in order to correlate the non-covalent interactions in these structures with theсonclusions from the theoretical analysis of solubility carried out by Cysewski (J. Mol. Model 24:112, 2018).

Tantardini C. , Arkipov S.G. , Cherkashina K.A. , Kil’met’ev A.S. , Boldyreva E.V.
Synthesis and Crystal Structure of a Meloxicam Co-Crystal with Benzoic Acid
Structural Chemistry. 2018. V.29. N6. P.1867–1874. DOI: 10.1007/s11224-018-1166-5 WOS Scopus РИНЦ РИНЦ AN OpenAlex

Submitted:	Jun 18, 2018
Accepted:	Jul 16, 2018
Published online:	Jul 25, 2018
Published print:	Dec 1, 2018

Web of science:	WOS:000451767200027
Scopus:	2-s2.0-85050674493
Elibrary:	41793303 \| 38616208
Chemical Abstracts:	2018:1428920
OpenAlex:	W2883590378

DB	Citing
Scopus	10
Elibrary	10 1
Web of science	10
OpenAlex	12