Luminescence Spectroscopy as a Tool to Study the Amorphization of Indomethacin upon Co-Grinding with Polymers | Sciact - CRIS-система Института катализа

Luminescence Spectroscopy as a Tool to Study the Amorphization of Indomethacin upon Co-Grinding with Polymers Научная публикация

Журнал

Doklady Physical Chemistry
ISSN: 0012-5016 , E-ISSN: 1608-3121

Вых. Данные

Год: 2018, Том: 480, Номер: 2, Страницы: 77-80 Страниц : 4 DOI: 10.1134/s0012501618060015

Ключевые слова

MOLECULAR DISPERSIONS; STABILITY

Авторы

Politov A. A. ^1,2 , Shakhtshneider T. P. ^1,2 , Boldyreva E. V. ^1,2 , Boldyrev V. V. ^1,2

Организации

1	Institute of Solid-State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630128 Russia
2	Novosibirsk National Research State University, Novosibirsk, 630090 Russia

Информация о финансировании (1)

Сибирское отделение Российской академии наук

II.2П/V.44-11

The possibility of using luminescence spectroscopy to study even the early stages of the amorphization of active pharmaceutical ingredients (APIs) during their co-grinding with different polymers has been demonstrated using indomethacin as an example. Amorphization of an API is observed only on co-grinding with those polymers that have functional groups capable of interacting with the API to form supramolecular complexes. It is the formation of supramolecular complexes due to the chemical affinity between them, rather than local heating caused by plastic deformation of an API or of a polymer, that is responsible for the amorphization of the API on co-grinding with selected polymers. It has also been shown that luminescence spectroscopy can be a sensitive method of monitoring the crystallization of the amorphous phase of APIs during storage of API mechanocomposites with polymers depending on temperature and relative humidity.

Politov A.A. , Shakhtshneider T.P. , Boldyreva E.V. , Boldyrev V.V.
Luminescence Spectroscopy as a Tool to Study the Amorphization of Indomethacin upon Co-Grinding with Polymers
Doklady Physical Chemistry. 2018. V.480. N2. P.77-80. DOI: 10.1134/s0012501618060015 WOS Scopus РИНЦ CAPlus OpenAlex

Политов А.А. , Шахтшнейдер Т.П. , Болдырева Е.В. , Болдырев В.В.
Возможности применения люминесцентной спектроскопии для исследования аморфизации индометацина при совместной механической обработке с полимерами
Доклады Академии наук. 2018. Т.480. №5. С.559-561. DOI: 10.7868/S0869565218050122 РИНЦ OpenAlex

Поступила в редакцию:	28 нояб. 2017 г.
Опубликована в печати:	1 июн. 2018 г.
Опубликована online:	14 июл. 2018 г.

Web of science:	WOS:000438822500001
Scopus:	2-s2.0-85050145505
РИНЦ:	35756923
Chemical Abstracts:	2018:1328837
OpenAlex:	W2883077674

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