Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane | Sciact - CRIS-система Института катализа

Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane Научная публикация

Журнал

ChemPhysChem
ISSN: 1439-4235 , E-ISSN: 1439-7641

Вых. Данные

Год: 2018, Том: 19, Номер: 20, Страницы: 2621-2626 Страниц : 6 DOI: 10.1002/cphc.201800690

Ключевые слова

contrast agent; cyclopropane; hydrogenation; hyperpolarization; parahydrogen-induced polarization

Авторы

Salnikov Oleg G. ^1,2 , Kovtunov Kirill V. ^1,2 , Nikolaou Panayiotis ³ , Kovtunova Larisa M. ^2,4 , Bukhtiyarov Valerii I. ^2,4 , Koptyug Igor V. ^1,2 , Chekmenev Eduard Y. ^3,5,6

Организации

1	International Tomography Center, SB RAS, Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia
3	Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Medical Center, Nashville, TN, United States
4	Boreskov Institute of Catalysis, SB RAS, Novosibirsk, Russia
5	Russian Academy of Sciences, Moscow, Russia
6	Department of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), Detroit, MI, United States

Информация о финансировании (11)

1	Российский научный фонд	17-73-20030
2	Федеральное агентство научных организаций России	0333-2018-0006 (II.1.13.1.)
3	Федеральное агентство научных организаций России	0333-2017-0002
4	National Science Foundation	CHE-1416268
5	National Science Foundation	CHE-1416432
6	National Institutes of Health	1R21EB020323
7	National Institutes of Health	1R21CA220137
8	United States Department of Defense	W81XWH-15-1-0271
9	United States Department of Defense	W81XWH-15-1-0272
10	Российский фонд фундаментальных исследований	17-54-33037
11	Федеральное агентство научных организаций России	0303-2016-0004

Hyperpolarized gases revolutionize functional pulmonary imaging. Hyperpolarized propane is a promising emerging contrast agent for pulmonary MRI. Unlike hyperpolarized noble gases, proton‐hyperpolarized propane gas can be imaged using conventional MRI scanners with proton imaging capability. Moreover, it is non‐toxic odorless anesthetic. Furthermore, propane hyperpolarization can be accomplished by pairwise addition of parahydrogen to propylene. Here, we demonstrate the feasibility of propane hyperpolarization via hydrogenation of cyclopropane with parahydrogen. 1H propane polarization up to 2.4 % is demonstrated here using 82 % parahydrogen enrichment and heterogeneous Rh/TiO2 hydrogenation catalyst. This level of polarization is several times greater than that obtained with propylene as a precursor under the same conditions despite the fact that direct pairwise addition of parahydrogen to cyclopropane may also lead to formation of propane with NMR‐invisible hyperpolarization due to magnetic equivalence of nascent parahydrogen protons in two CH3 groups. NMR‐visible hyperpolarized propane demonstrated here can be formed only via a reaction pathway involving cleavage of at least one C–H bond in the reactant molecule. The resulting NMR signal enhancement of hyperpolarized propane was sufficient for 2D gradient echo MRI of ∼5.5 mL phantom with 1×1 mm2 spatial resolution and 64×64 imaging matrix despite relatively low chemical conversion of cyclopropane substrate.

Salnikov O.G. , Kovtunov K.V. , Nikolaou P. , Kovtunova L.M. , Bukhtiyarov V.I. , Koptyug I.V. , Chekmenev E.Y.
Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane

ChemPhysChem. 2018. V.19. N20. P.2621-2626. DOI: 10.1002/cphc.201800690 WOS Scopus РИНЦ CAPlus PMID OpenAlex OpenAlex

Полный текст от издателя

Поступила в редакцию:	18 июл. 2018 г.
Принята к публикации:	23 июл. 2018 г.
Опубликована online:	7 авг. 2018 г.
Опубликована в печати:	19 окт. 2018 г.

Web of science:	WOS:000448062900003
Scopus:	2-s2.0-85052951382
РИНЦ:	41781531
Chemical Abstracts:	2018:1461742
PMID (PubMed):	30039565
OpenAlex:	W2884826061 \| W2897888484

БД	Цитирований
Web of science	17
Scopus	19
РИНЦ	19
OpenAlex	19