Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment | Sciact - CRIS-system of Boreskov Institute of Catalysis

Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment Full article

Journal

Materials
ISSN: 1996-1944

Output data

Year: 2018, Volume: 11, Number: 11, Article number : 2176, Pages count : 16 DOI: 10.3390/ma11112176

Tags

drug release; electrospinning; paclitaxel; polycaprolactone; 3D matrix

Authors

Kuznetsov Konstantin A. ^1,2 , Stepanova Alena O. ^1,2 , Kvon Ren I. ³ , Douglas Timothy E.L. ^4,5 , Kuznetsov Nikita A. ¹ , Chernonosova Vera S. ^1,2 , Zaporozhchenko Ivan A. ^1,2 , Kharkova Maria V. ¹ , Romanova Irina V. ¹ , Karpenko Andrey A. ² , Laktionov Pavel P. ^1,2

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia
2	Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk 630055, Russia
3	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia
4	Engineering Department, Lancaster University, Lancaster LA1 4YW, UK
5	Materials Science Institute (MSI), Lancaster University, Lancaster LA1 4YW, UK

Funding (1)

Russian Science Foundation

18-15-00080

Paclitaxel is a natural, highly lipophilic anti proliferative drug widely used in medicine. We have studied the release of tritium-labeled paclitaxel (3H-PTX) from matrices destined for the coating of vascular stents and produced by the electrospinning method from the solutions of polycaprolactone (PCL) with paclitaxel (PTX) in hexafluoisopropanol (HFIP) and/or solutions of PCL with PTX and human serum albumin (HSA) in HFIP or HIFP-dimethyl sulphoxide (DMSO) blend. The release of PTX has been shown to depend on the composition of electrospinning solution, as well as the surrounding medium, particularly the concentration of free PTX and PTX-binding biomolecules present in human serum. It was shown that 3D matrices can completely release PTX without weight loss. Two-phase PTX release from optimized 3D matrices was obtained: ~27% of PTX was released in the first day, another 8% were released over the next 26 days. Wherein ~2.8%, ~2.3%, and ~0.25% of PTX was released on day 3, 9, and 27, respectively. Considering PTX toxicity, the rate of its diffusion through the arterial wall, and the data obtained the minimum cytostatic dose of the drug in the arterial wall will be maintained for at least three months.

Kuznetsov K.A. , Stepanova A.O. , Kvon R.I. , Douglas T.E.L. , Kuznetsov N.A. , Chernonosova V.S. , Zaporozhchenko I.A. , Kharkova M.V. , Romanova I.V. , Karpenko A.A. , Laktionov P.P.
Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment

Materials. 2018. V.11. N11. 2176 :1-16. DOI: 10.3390/ma11112176 WOS Scopus РИНЦ AN PMID OpenAlex

Full text from publisher

Submitted:	Oct 11, 2018
Accepted:	Oct 31, 2018
Published print:	Nov 2, 2018
Published online:	Nov 2, 2018

Web of science:	WOS:000451755500111
Scopus:	2-s2.0-85055985659
Elibrary:	37418282
Chemical Abstracts:	2019:2010976
PMID:	30400260
OpenAlex:	W2896192906

DB	Citing
Scopus	15
Web of science	15
Elibrary	16
OpenAlex	17