Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE | Sciact - CRIS-system of Boreskov Institute of Catalysis

Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE Full article

Journal

The Journal of Physical Chemistry A
ISSN: 1089-5639 , E-ISSN: 1520-5215

Output data

Year: 2018, Volume: 122, Number: 46, Pages: 9107-9114 Pages count : 8 DOI: 10.1021/acs.jpca.8b07163

Tags

Polarization

Authors

Pravdivtsev Andrey N. ¹ , Skovpin Ivan V. ^2,3 , Svyatova Alexandra I. ^2,3 , Chukanov Nikita V. ^2,3 , Kovtunova Larisa M. ^3,4 , Bukhtiyarov Valerii I. ⁴ , Chekmenev Eduard Y. ^5,6 , Kovtunov Kirill V. ^2,3 , Koptyug Igor V. ^2,3 , Hövener Jan-Bernd ¹

Affiliations

1	Section for Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, Am Botanischen Garten 14, 24118 Kiel, Germany
2	International Tomography Center, Siberian Branch of the Russian Academy of the Sciences, Institutskaya st. 3 A, 630090 Novosibirsk, Russia
3	Novosibirsk State University, Pirogova st. 2, 630090 Novosibirsk, Russia
4	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of the Sciences, 5 Acad. Lavrentiev Ave., 630090 Novosibirsk, Russia
5	Department of Chemistry, Wayne State University, Karmanos Cancer Institute (KCI), Integrative Biosciences (Ibio), Detroit, Michigan 48202, United States
6	Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow, Russia

Funding (11)

1	Russian Foundation for Basic Research	16-33-60198
2	Russian Science Foundation	17-73-20030
3	United States Department of Defense	W81XWH-12-1-0159/BC112431
4	National Science Foundation	CHE-1416268
5	German Research Foundation	HO 4604/2-1
6	National Science Foundation	CHE-1836308
7	National Institutes of Health	1R21EB020323
8	National Institutes of Health	1R21CA220137
9	United States Department of Defense	W81XWH-15-1-0271
10	Federal Agency for Scientific Organizations	0333-2017-0002
11	European Commission	122-09-053

Signal Amplification By Reversible Exchange (SABRE) is a new and rapidly developing hyperpolarization technique. The recent discovery of Spin-Lock Induced Crossing SABRE (SLIC-SABRE) showed that high field hyperpolarization transfer techniques developed so far were optimized for singlet spin order that does not coincide with the experimentally produced spin state. Here, we investigated the SLIC-SABRE approach and the most advanced quantitative theoretical SABRE model to date. Our goal is to achieve the highest possible polarization with SLIC-SABRE at high field using the standard SABRE system, IrIMes catalyst with pyridine. We demonstrated the accuracy of the SABRE model describing the effects of various physical parameters such as the amplitude and frequency of the radio frequency field, and the effects of chemical parameters such as the exchange rate constants. By fitting the model to the experimental data, the effective life time of the SABRE complex was estimated, as well as the entropy and enthalpy of the complex-dissociation reaction. We show, for the first time, that this SLIC-SABRE model can be useful for the evaluation of the chemical exchange parameters that are very important for the production of highly polarized contrast agents via SABRE.

Pravdivtsev A.N. , Skovpin I.V. , Svyatova A.I. , Chukanov N.V. , Kovtunova L.M. , Bukhtiyarov V.I. , Chekmenev E.Y. , Kovtunov K.V. , Koptyug I.V. , Hövener J-B.
Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE

The Journal of Physical Chemistry A. 2018. V.122. N46. P.9107-9114. DOI: 10.1021/acs.jpca.8b07163 WOS Scopus РИНЦ OpenAlex AN PMID

Full text from publisher

Submitted:	Jul 25, 2018
Accepted:	Oct 4, 2018
Published online:	Oct 8, 2018
Published print:	Nov 21, 2018

≡ Web of science:	WOS:000451495800014
≡ Scopus:	2-s2.0-85056571688
≡ Elibrary:	38622414
≡ OpenAlex:	W2896421511
≡ Chemical Abstracts:	2018:1866724
≡ PMID:	30295488

≡ Scopus	40	Сбор данных от 15.02.2026
≡ Web of science	40	Сбор данных от 13.02.2026
≡ Elibrary	40	Сбор данных от 15.02.2026
≡ OpenAlex	44	Сбор данных от 15.02.2026