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Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression Научная публикация

Журнал European Biophysics Journal with Biophysics Letters
ISSN: 0175-7571 , E-ISSN: 1432-1017
Вых. Данные Год: 2019, Том: 48, Номер: 3, Страницы: 297–302 Страниц : 6 DOI: 10.1007/s00249-019-01358-3
Ключевые слова Bistability; Transient kinetics; Gene expression; Mean-feld kinetic equations; Monte Carlo simulations; Drug delivery
Авторы Zhdanov Vladimir P. 1,2
Организации
1 Section of Biological Physics, Department of Physics, Chalmers University of Technology, Göteborg, Sweden
2 Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk, Russia

Информация о финансировании (2)

1 Федеральное агентство научных организаций России 0303-2016-0001
2 Stiftelsen för strategisk forskning IRC15-0065

Реферат: After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein.
Библиографическая ссылка: Zhdanov V.P.
Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression
European Biophysics Journal with Biophysics Letters. 2019. V.48. N3. P.297–302. DOI: 10.1007/s00249-019-01358-3 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Даты:
Поступила в редакцию: 12 авг. 2018 г.
Принята к публикации: 9 мар. 2019 г.
Опубликована online: 22 мар. 2019 г.
Опубликована в печати: 1 апр. 2019 г.
Идентификаторы БД:
Web of science: WOS:000463833800008
Scopus: 2-s2.0-85064082036
РИНЦ: 38689097
Chemical Abstracts: 2019:798230
PMID (PubMed): 30903265
OpenAlex: W2923114352
Цитирование в БД:
БД Цитирований
Scopus 2
Web of science 2
РИНЦ 2
OpenAlex 2
Альметрики: