Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression Научная публикация
| Журнал |
European Biophysics Journal with Biophysics Letters
ISSN: 0175-7571 , E-ISSN: 1432-1017 |
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| Вых. Данные | Год: 2019, Том: 48, Номер: 3, Страницы: 297–302 Страниц : 6 DOI: 10.1007/s00249-019-01358-3 | ||||
| Ключевые слова | Bistability; Transient kinetics; Gene expression; Mean-feld kinetic equations; Monte Carlo simulations; Drug delivery | ||||
| Авторы |
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| Организации |
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Информация о финансировании (2)
| 1 | Федеральное агентство научных организаций России | 0303-2016-0001 |
| 2 | Stiftelsen för strategisk forskning | IRC15-0065 |
Реферат:
After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein.
Библиографическая ссылка:
Zhdanov V.P.
Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression
European Biophysics Journal with Biophysics Letters. 2019. V.48. N3. P.297–302. DOI: 10.1007/s00249-019-01358-3 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression
European Biophysics Journal with Biophysics Letters. 2019. V.48. N3. P.297–302. DOI: 10.1007/s00249-019-01358-3 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Даты:
| Поступила в редакцию: | 12 авг. 2018 г. |
| Принята к публикации: | 9 мар. 2019 г. |
| Опубликована online: | 22 мар. 2019 г. |
| Опубликована в печати: | 1 апр. 2019 г. |
Идентификаторы БД:
| Web of science: | WOS:000463833800008 |
| Scopus: | 2-s2.0-85064082036 |
| РИНЦ: | 38689097 |
| Chemical Abstracts: | 2019:798230 |
| PMID (PubMed): | 30903265 |
| OpenAlex: | W2923114352 |