The Fatty Acid Profiles of the Red Blood Cell Membrane and Blood Serum in Inflammatory Bowel Disease Patients | Sciact - CRIS-system of Boreskov Institute of Catalysis

The Fatty Acid Profiles of the Red Blood Cell Membrane and Blood Serum in Inflammatory Bowel Disease Patients Conference Abstracts

Conference

28th International Conference on Chelation -A Landmark on Chelation Science and Medicine. 7th International Conference on Oncology and Anticancer Research. 10th International Conference RAHMS: Recent Advances in Health and Medical Sciences
28 Jun - 3 Jul 2019 , Paphos

Source

"Twenty Eighth International Conference on Chelation" - "Tenth International Conference on Recent Advances in Health and Medical Sciences" - "Seventh International Conference on Oncology and Anticancer Research" 28TH ICOC - 10TH RAHMS - 7TH ICOAR
Compilation, PAPHOS GENERAL HOSPITAL. Cyprus.2019. 44 c. РИНЦ

Output data

Year: 2019, Pages: 28 Pages count : 1

Authors

Kruchinina M.V. ¹ , Azgaldyan A.V. ¹ , Svetlova I.O. ¹ , Gromov A.A. ¹ , Shashkov M.V. ² , Sokolova A.S. ³ , Kruchinin V.N. ⁴

Affiliations

1	Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10, Lavrentjev avenue, Novosibirsk, 630090 RUSSIA
2	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, 5, Lavrent'ev prospect, Novosibirsk, 630090
3	Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, 9, Academician Lavrentiev Ave., Novosibirsk, 630090
4	Rzhanov Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, 13, Acad. Lavrentjeva avenue, Novosibirsk, 630090

The aim of the work was to investigate changes in the fatty acid composition of red blood cells membranes (RBC) and serum (BS) in patients with ulcerative colitis (UC) and Crohn's disease (CD) for possible differential diagnosis. Methods. 18 patients with UC, 19- with CD (35.2 + 4.7 years) and 20 healthy controls were examined. The study of fatty acids (FAs) composition of RBC and BS was carried out using GC/MS system triple quad Agilent 7000B (USA). In BS of patients with UC reduced levels of myristin C14:0, α-linolenic C18: 3 n-3 and elevated levels of stearic C18:0, dihomo-γ-linolenic C20:3 n-6 were detected than those in healthy controls (p < 0.03-0.05); as for the membranes of RBC - a lower content of oleic C18:1; c9, elaidic C18:1; t9 and high level of C20:3 n-6 were determined (p <0.01-0.05) . In patients with CD the BS levels of C14:0, C16:2 n-6, C22:4 n-3 were lower, and arachidonic acid (AA) C20:4 n-6 were higher compared to the ones in controls (p <0.02-0.05). The data obtained allowed us to create a diagnostic panel for distinguishing the patients with UC and CD with sensitivity of 68% and specificity of 76%, which can be useful for the purposes of differential diagnosis.

Kruchinina M.V. , Azgaldyan A.V. , Svetlova I.O. , Gromov A.A. , Shashkov M.V. , Sokolova A.S. , Kruchinin V.N.
The Fatty Acid Profiles of the Red Blood Cell Membrane and Blood Serum in Inflammatory Bowel Disease Patients
In compilation "Twenty Eighth International Conference on Chelation" - "Tenth International Conference on Recent Advances in Health and Medical Sciences" - "Seventh International Conference on Oncology and Anticancer Research" 28TH ICOC - 10TH RAHMS - 7TH ICOAR. – PAPHOS GENERAL HOSPITAL., 2019. – C.28. РИНЦ

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