The Possibility of Using of Fatty Acids in Blood Serum and Erythrocytes for Identifying Adenomatous Polyps, Early Colorectal Cancer and Assessing the Progression of the Disease | Sciact - CRIS-system of Boreskov Institute of Catalysis

The Possibility of Using of Fatty Acids in Blood Serum and Erythrocytes for Identifying Adenomatous Polyps, Early Colorectal Cancer and Assessing the Progression of the Disease Conference Abstracts

Conference

28th International Conference on Chelation -A Landmark on Chelation Science and Medicine. 7th International Conference on Oncology and Anticancer Research. 10th International Conference RAHMS: Recent Advances in Health and Medical Sciences
28 Jun - 3 Jul 2019 , Paphos

Source

"Twenty Eighth International Conference on Chelation" - "Tenth International Conference on Recent Advances in Health and Medical Sciences" - "Seventh International Conference on Oncology and Anticancer Research" 28TH ICOC - 10TH RAHMS - 7TH ICOAR
Compilation, PAPHOS GENERAL HOSPITAL. Cyprus.2019. 44 c. РИНЦ

Output data

Year: 2019, Pages: 27 Pages count : 5

Tags

FATTY ACIDS, BLOOD SERUM, ERYTHROCYTES, ADENOMATOUS POLYPS, COLORECTAL CANCER

Authors

Kruchinina M.V. ¹ , Prudnikova Ya.I. ¹ , Kurilovich S.A. ¹ , Gromov A.A. ¹ , Shashkov M.V. ² , Sokolova A.S. ³ , Yakovina I.N. ⁴ , Bannova N.A. ⁴ , Kruchinin V.N ⁵

Affiliations

1	Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10, Lavrentjev avenue, Novosibirsk, 630090 RUSSIA
2	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, 5, Lavrent'ev prospect, Novosibirsk, 630090
3	Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, 9, Academician Lavrentiev Ave., Novosibirsk, 630090
4	Novosibirsk State Technical University, 20, K. Marx street, Novosibirsk, 630073
5	Rzhanov Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, 13, Acad. Lavrentjeva avenue, Novosibirsk, 630090

We aimed to investigate the role of blood serum (BS) and red blood cells (RBCs) membrane levels of fatty acids (FAs) in the development of CRC and the possibility of FA using for diagnostic purposes. We investigated the FAs composition in BS, RBCs membranes from 95 patients with CRC (56+8 years old), 23 ones with adenomatous polyps (AP) and 28 healthy controls by the method of gas chromatography (GC/MS system triple quad Agilent 7000B(USA). The lipidomic profiles also were compared between early (n=44) and late stages (n=51) of CRC. Compared to the controls BS n-3 PUFA (p<0.001), C20:5 n-3 (p=0.016), C22:6 n-3 (p<0.001), n-6 PUFA (p<0.001) and C18:2 n-6 (p=0.002) in the AP group showed significantly reduced. At the same time compared to the AP group, n-3 PUFA (p=0.001), C22:6 n-3 (p=0.003), n-6 PUFA (p<0.001), C18:2 n-6 (p=0.002) and C20:4 n-6 (p=0.016) showed significantly increased in the CRC group. The ratio of n-6 PUFA and n-3 PUFA (p=0.001) and ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (p<0.001) showed significantly increased in the AP group then those in healthy people. FAs panels should be considered promising for CRC diagnostics, including early.

Kruchinina M.V. , Prudnikova Y.I. , Kurilovich S.A. , Gromov A.A. , Shashkov M.V. , Sokolova A.S. , Yakovina I.N. , Bannova N.A. , Kruchinin V.N.
The Possibility of Using of Fatty Acids in Blood Serum and Erythrocytes for Identifying Adenomatous Polyps, Early Colorectal Cancer and Assessing the Progression of the Disease
In compilation "Twenty Eighth International Conference on Chelation" - "Tenth International Conference on Recent Advances in Health and Medical Sciences" - "Seventh International Conference on Oncology and Anticancer Research" 28TH ICOC - 10TH RAHMS - 7TH ICOAR. – PAPHOS GENERAL HOSPITAL., 2019. – C.27. РИНЦ

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