Influence of Crystal Packing on the Mechanism of Decomposition of the Acetonitrile-Solvated Co-crystal of Piroxicam and Succinic Acid | Sciact - CRIS-system of Boreskov Institute of Catalysis

Influence of Crystal Packing on the Mechanism of Decomposition of the Acetonitrile-Solvated Co-crystal of Piroxicam and Succinic Acid Full article

Journal

Crystal Growth and Design
ISSN: 1528-7483 , E-ISSN: 1528-7505

Output data

Year: 2019, Volume: 19, Number: 12, Pages: 7315-7323 Pages count : 9 DOI: 10.1021/acs.cgd.9b01189

Tags

Piroxicam, Co-crystal, Thermal Expansion, Thermal Desolvation, Mechanical Desolvation, Thermal Decomposition

Authors

Liu Xiaojiao ¹ , Tang Chiu C. ² , Boldyreva Elena V. ^3,4 , Pulham Colin R. ¹

Affiliations

1	EaStCHEM School of Chemistry and Centre for Science at Extreme Conditions, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, Scotland, United Kingdom
2	Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom
3	Boreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, pr. Lavrentieva 5, Novosibirsk 630090, Russian Federation
4	Novosibirsk State University, ul. Pirogova, 2, Novosibirsk 630090, Russian Federation

Funding (2)

1	Ministry of Science and Higher Education of the Russian Federation	0239-2019-0003
2	Foreign & Commonwealth Office	R45778

Variable-temperature single-crystal and powder X-ray diffraction techniques have been used to study the thermal and mechanical decomposition of the acetonitrile solvate of the co-crystal formed between piroxicam and succinic acid (PRXSA-ACN). The results show that the thermal expansion behavior of PRXSA-ACN is highly anisotropic and can be correlated with structural features of the crystal lattice. Thermally-induced desolvation of PRXSA-ACN led initially to the formation of the α-form of piroxicam and the 1:1 piroxicam:succinic acid co-crystal (PRXSA), and this can be rationalized on the basis of the crystal structure of PRXSA-ACN and its thermal expansion behavior. Subsequent decomposition of PRXSA produced amorphous succinic acid and the thermodynamically more stable β-form of piroxicam. The α- and β-forms co-existed up until the melting point of the α-form, at which point the sample recrystallized to give the β-form of piroxicam. Mechanical treatment (light grinding) of PRXSA-ACN resulted in mild structural damage to the crystal structure and this led to subsequent desolvation.

Liu X. , Tang C.C. , Boldyreva E.V. , Pulham C.R.
Influence of Crystal Packing on the Mechanism of Decomposition of the Acetonitrile-Solvated Co-crystal of Piroxicam and Succinic Acid
Crystal Growth and Design. 2019. V.19. N12. P.7315-7323. DOI: 10.1021/acs.cgd.9b01189 WOS Scopus РИНЦ ANCAN OpenAlex

Submitted:	Sep 8, 2019
Published online:	Nov 7, 2019
Published print:	Dec 4, 2019

Web of science:	WOS:000501621100056
Scopus:	2-s2.0-85075680329
Elibrary:	43208831
Chemical Abstracts:	2019:2109608
Chemical Abstracts (print):	171:558337
OpenAlex:	W2985389100

DB	Citing
Scopus	6
Web of science	7
Elibrary	3
OpenAlex	7