Abstract: The conventional mean-field kinetic models describing the interplay of cancer and the immune system are temporal and predict exponential growth or elimination of the population of tumour cells provided their number is small and their effect on the immune system is negligible. More complex kinetics are associated with non-linear features of the response of the immune system. The generic model presented in this communication takes into account that the rates of the birth and death of tumour cells inside a tumour spheroid can significantly depend on the radial coordinate due to diffusion limitations in the supply of nutrients and/or transport of the species (cells and proteins) belonging to the immune system. In this case, non-trivial kinetic regimes are shown to be possible even without appreciable perturbation of the immune system. © 2019, The Author(s).

Cite: Zhdanov V.P.
Spatio-Temporal Aspects of the Interplay of Cancer and the Immune System
Journal of Biological Physics. 2019. V.45. N4. P.395-400. DOI: 10.1007/s10867-019-09535-3 WOS Scopus РИНЦ PMID OpenAlex

Files: Full text from publisher

Dates:

Submitted:	Sep 2, 2019
Accepted:	Nov 7, 2019
Published online:	Nov 26, 2019
Published print:	Dec 1, 2019

Identifiers:

Web of science:	WOS:000511721100005
Scopus:	2-s2.0-85075616588
Elibrary:	43214204
PMID:	31773382
OpenAlex:	W2990074654

Citing:

DB	Citing
Scopus	3
Web of science	3
Elibrary	3
OpenAlex	2

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