Analysis of the Initiation of Viral Infection under Flow Conditions with Applications to Transmission in Feed | Sciact - CRIS-система Института катализа

Analysis of the Initiation of Viral Infection under Flow Conditions with Applications to Transmission in Feed Научная публикация

Журнал

Biosystems
ISSN: 0303-2647 , E-ISSN: 1872-8324

Вых. Данные

Год: 2020, Том: 196, Номер статьи : 104184, Страниц : 7 DOI: 10.1016/j.biosystems.2020.104184

Ключевые слова

Diffusion; Flow; Growth; Infection; Kinetic models; Viruses

Авторы

Zhdanov Vladimir P. ^1,2 , Jackman Joshua A. ³

Организации

1	Section of Biological Physics, Department of Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden
2	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia
3	School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea

Информация о финансировании (1)

National Research Foundation of Korea

2020R1C1C1004385

While kinetic models are widely used to describe viral infection at various levels, most of them are focused on temporal aspects and understanding of corresponding spatio-temporal aspects remains limited. In this work, our attention is focused on the initial stage of infection of immobile cells by virus particles (“virions”) under flow conditions with diffusion. A practical example of this scenario occurs when humans or animals consume food from virion-containing sources. Mathematically, such situations can be described by using a model constructed in analogy with those employed in chemical engineering for analysis of the function of a plug-flow reactor with dispersion. As in the temporal case, the corresponding spatio-temporal model predicts either the transition to a steady state or exponential growth of the populations of virions and infected cells. The spatial distributions of these species are similar in both of these regimes. In particular, the maximums of the populations are shifted to the upper boundary of the infected region. The results illustrating these conclusions were obtained analytically and by employing numerical calculations without and with the dependence of the kinetic parameters on the coordinate. The model proposed has also been used in order to illustrate the effect of antiviral feed additives on feedborne infection towards curbing disease transmission. © 2020 Elsevier B.V.

Zhdanov V.P. , Jackman J.A.
Analysis of the Initiation of Viral Infection under Flow Conditions with Applications to Transmission in Feed

Biosystems. 2020. V.196. 104184 :1-7. DOI: 10.1016/j.biosystems.2020.104184 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex

Полный текст от издателя

Поступила в редакцию:	27 апр. 2020 г.
Принята к публикации:	7 июн. 2020 г.
Опубликована online:	9 июн. 2020 г.
Опубликована в печати:	1 окт. 2020 г.

Web of science:	WOS:000564562900005
Scopus:	2-s2.0-85086602635
РИНЦ:	43301024
Chemical Abstracts:	2020:1215592
Chemical Abstracts (print):	173:127726
PMID (PubMed):	32531420
OpenAlex:	W3034371158

БД	Цитирований
Scopus	4
Web of science	4
РИНЦ	3
OpenAlex	4