Abstract: The interaction of exosomes (cell-secreted ∼ 100 nm-sized extracellular vesicles) or membrane-enveloped virions with cellular lipid membranes is often mediated by relatively weak ligand-receptor bonds. Interactions of this type can be studied using vesicles and observing their attachment to receptors located in a lipid bilayer formed at a solid surface. The contact region between a vesicle and the supported lipid bilayer and accordingly the number of ligand-receptor pairs there can be increased by deforming a vesicle. Herein, I (i) estimate theoretically the corresponding deformation energy assuming a disk-like or elongated shape of vesicles, (ii) present the equations allowing one to track such deformations by employing total internal reflection fluorescence microscopy and surface plasmon resonance, and (iii) briefly discuss some related experimental studies. © 2020, The Author(s).

Cite: Zhdanov V.P.
Ligand-Receptor-Mediated Attachment of Lipid Vesicles to a Supported Lipid Bilayer
European Biophysics Journal with Biophysics Letters. 2020. V.49. N5. P.395-400. DOI: 10.1007/s00249-020-01441-0 WOS Scopus РИНЦ РИНЦ ANCAN PMID OpenAlex

Files: Full text from publisher

Dates:

Submitted:	Feb 16, 2020
Accepted:	Jun 1, 2020
Published online:	Jun 17, 2020
Published print:	Jul 1, 2020

Identifiers:

Web of science:	WOS:000540948600001
Scopus:	2-s2.0-85086576079
Elibrary:	43301481 | 45492700
Chemical Abstracts:	2020:1218145
Chemical Abstracts (print):	173:573647
PMID:	32556429
OpenAlex:	W3035769530

Citing:

DB	Citing
Scopus	6
Web of science	6
Elibrary	6
OpenAlex	5

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