Sciact
  • EN
  • RU

Multicomponent Synthesis of Unsymmetrical 5-nitropyridines Full article

Journal Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353
Output data Year: 2019, Volume: 54, Number: 12, Pages: 1127-1130 Pages count : 4 DOI: 10.1007/s10593-019-02403-x
Tags 5-nitro-1,4-dihydropyridines, 5(3)-nitropyridines, green chemistry, multicomponent reaction
Authors Koveza Vladislav A. 1 , Kulakov Ivan V. 2,3 , Shulgau Zarina T. 3 , Seilkhanov Tulegen M. 4
Affiliations
1 F. M. Dostoevskii Omsk State University
2 Institute of Chemistry, Tyumen State University
3 Republican State Enterprise ''National Center for Biotechnology'' under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan
4 Sh. Ualikhanov Kokshetau State University

Abstract: Reaction of 2-nitroacetophenone, furfurol, β-dicarbonyl compounds, and ammonium acetate led to 3-substituted 4-(2-furyl)-5-nitro-6-phenyl-1,4-dihydropyridines, which were oxidized with potassium nitrate in the presence of copper(II) nitrate (10 mol %), leading to the respective 5-nitro-6-phenylpyridines. The performed multicomponent reactions met the general principles of green chemistry. Synthesis of these unsymmetrical 5-nitro-6-phenylpyridines via the formation of 1,4-dihydropyridine intermediates under the conditions of multicomponent reaction significantly shortened the overall reaction time, decreased the number of steps, and improved the yield.
Cite: Koveza V.A. , Kulakov I.V. , Shulgau Z.T. , Seilkhanov T.M.
Multicomponent Synthesis of Unsymmetrical 5-nitropyridines
Chemistry of Heterocyclic Compounds. 2019. V.54. N12. P.1127-1130. DOI: 10.1007/s10593-019-02403-x WOS Scopus РИНЦ ANCAN OpenAlex
Original: Ковеза В.А. , Кулаков И.В. , Шульгау З.Т. , Сейлханов Т.М.
Многокомпонентный синтез несимметричных 5-нитропиридинов
Химия гетероциклических соединений. 2018. Т.54. №12. С.1127-1130.
Dates:
Submitted: Sep 4, 2018
Accepted: Nov 15, 2018
Published print: Dec 1, 2018
Published online: Jan 17, 2019
Identifiers:
Web of science: WOS:000461553300007
Scopus: 2-s2.0-85060223021
Elibrary: 38681467
Chemical Abstracts: 2019:590666
Chemical Abstracts (print): 170:488423
OpenAlex: W2908699996
Citing:
DB Citing
Web of science 11
Scopus 11
OpenAlex 11
Altmetrics: