Effect of the Selected Inorganic Carriers on the Properties of Mechanocomposites with Drugs | Sciact - CRIS-system of Boreskov Institute of Catalysis

Effect of the Selected Inorganic Carriers on the Properties of Mechanocomposites with Drugs Full article

Journal

Doklady Chemistry
ISSN: 0012-5008 , E-ISSN: 1608-3113

Output data

Year: 2014, Volume: 456, Number: Part 2, Pages: 98-102 Pages count : 5 DOI: 10.1134/S0012500814060044

Tags

Piroxicam; Boehmite; Drug Substance; Gibbsite; Meloxicam

Authors

Shakhtshneider T.P. ^1,2 , Myz S.A. ¹ , Nizovskii A.I. ^3,4 , Kalinkin A.V. ³ , Boldyreva E.V. ^1,2 , Alex T.C. ⁵ , Kumar Rakesh ⁵

Affiliations

1	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, ul. Kutateladze 18, Novosibirsk, 630128 Russia
2	Novosibirsk State University, ul.Pirogova 2, Novosibirsk, 630090 Russia
3	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 5, Novosibirsk, 630090 Russia
4	Omsk State Technical University, pr.Mira 11, Omsk, 644050 Russia
5	National Metallurgical Laboratory, Jamshedpur, India

Funding (4)

1	Russian Foundation for Basic Research	09-03-92658
2	Russian Foundation for Basic Research	13-03-92704
3	The Ministry of Education and Science of the Russian Federation
4	Президиум РАН	ФНМ-03

We found several nontrivial effects that are important for the development of solubilization methods for poorly soluble drug substances by preparation of mechanocomposites with inorganic carriers. Indeed, drug substances having similar molecular structures and corresponding to the same class of oxicams behave in different ways when dissolved as parts of composites with the same inorganic components. With the same drug substance, the initial differences between the aluminum hydroxide forms used as inorganic carriers were manifested even upon mechanical activation in which the carrier was partly amorphized. The effect arising upon joint mechanical treatment of the drug substance and the carrier was much higher than upon mixing of the components that were separately mechanically pretreated. These effects are to be taken into account for choosing the excipients and for design of new drugs.

Shakhtshneider T.P. , Myz S.A. , Nizovskii A.I. , Kalinkin A.V. , Boldyreva E.V. , Alex T.C. , Kumar R.
Effect of the Selected Inorganic Carriers on the Properties of Mechanocomposites with Drugs
Doklady Chemistry. 2014. V.456. NPart 2. P.98-102. DOI: 10.1134/S0012500814060044 WOS Scopus РИНЦ ANCAN OpenAlex

Шахтшнейдер Т.П. , Мызь С.А. , Низовский А.И. , Калинкин А.В. , Болдырева Е.В. , Alex T. , Kumar R.
Влияние выбора неорганического носителя на свойства механокомпозитов с лекарственными веществами
Доклады Академии наук. 2014. Т.456. №5. С.556-560. DOI: 10.7868/S0869565214170149 РИНЦ OpenAlex

Submitted:	Feb 4, 2014
Published print:	Jun 1, 2014
Published online:	Jul 5, 2014

Web of science:	WOS:000339111100005
Scopus:	2-s2.0-84905371350
Elibrary:	23976371
Chemical Abstracts:	2014:1113990
Chemical Abstracts (print):	161:436381
OpenAlex:	W2001204381

DB	Citing
Web of science	1
Scopus	1
Elibrary	1
OpenAlex	1