Features of Metabolic Profiles of Blood Serum and Erythrocyte Membranes Associated with Metastasis in Colorectal Cancer | Sciact - CRIS-system of Boreskov Institute of Catalysis

Features of Metabolic Profiles of Blood Serum and Erythrocyte Membranes Associated with Metastasis in Colorectal Cancer Conference Abstracts

Conference

ESMO 22nd World Congress on Gastrointestinal Cancer
01-04 Jul 2020 , Lugano

Journal

Annals of Oncology
ISSN: 0923-7534 , E-ISSN: 1569-8041

Output data

Year: 2020, Volume: 31, Article number : P-3, Pages count : 2 DOI: 10.1016/j.annonc.2020.04.085

Authors

Kruchinina M. ¹ , Gromov A. ¹ , Kruchinin V. ² , Shashkov M. ³ , Sokolova A. ⁴ , Yakovina I. ⁵ , Bannova N. ⁵

Affiliations

1	Research Institute of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2	Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
3	Boreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
4	Vorozhtsov Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
5	Novosibirsk State Technical University, Novosibirsk, Russia

The aim of the work was to determine if, in patients with colorectal cancer, the serum metabolomic profile, erythrocyte fatty acid profile could be used to discriminate locoregional CRC from metastatic CRC, and to identify patients with liver metastases. Sera, erythrocyte membranes from 56 patients (63,2+9,4 years old) with colorectal adenocarcinoma were analyzed by GC-MS spectrometry (GC/MS system triple quad Agilent 7000B (USA). The metabolomic profiles were compared between the following groups: locoregional CRC (n = 20); liver metastases (n = 19) and extrahepatic metastases (n = 17). The control group consisted of 35 healthy people of comparable age. We found the list of metabolites capable of identifying differences between patients with liver metastases and extrahepatic metastases: serum levels of myristic acid (C14:0), linoleic acid (C18:2;n-6), phenylalanine, threonine were lower and glutamine, glucose, butanoic acid, histidine, mannose were more abundant in extrahepatic metastases in comparison with liver metastases patients (p<0,01-0,05). In erythrocyte membranes the decreased content of C12:0, С18:1;t9, C16:0/C18:2; n-6 and increased levels of C20:5;n-3, C20:4;n-6, C22:4;n-6, C22:5;n-3, (С20:3n-6 + C20:4n-6)/C18:2n-6 allowed us to distinguish extrahepatic from liver metastases (AUC 0.86, sensitivity 0.77, specificity 0.90). Significant changes in serum and erythrocyte metabolites associated with the various localization of CRC metastases were found. Created diagnostic panels should be considered promising for detecting occult metastases, selecting patients for surgical or chemotherapeutic treatment.

Kruchinina M. , Gromov A. , Kruchinin V. , Shashkov M. , Sokolova A. , Yakovina I. , Bannova N.
Features of Metabolic Profiles of Blood Serum and Erythrocyte Membranes Associated with Metastasis in Colorectal Cancer

Annals of Oncology. 2020. V.31. P-3 :1-2. DOI: 10.1016/j.annonc.2020.04.085 WOS РИНЦ OpenAlex

Full text from publisher

Published print:	Jul 1, 2020
Published online:	Jul 1, 2020

Web of science:	WOS:000558722000004
Elibrary:	43863467
OpenAlex:	W3041943014

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