Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides | Sciact - CRIS-system of Boreskov Institute of Catalysis

Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides Full article

Conference

12th Annual Conference YUCOMAT 2010
06-10 Sep 2010 , Herceg Novi

Journal

Acta Physica Polonica A
ISSN: 0587-4246 , E-ISSN: 1898-794X

Output data

Year: 2011, Volume: 120, Number: 2, Pages: 272-278 Pages count : 7 DOI: 10.12693/APhysPolA.120.272

Tags

METAL-COMPLEXES; PIROXICAM; NANOCOMPOSITES; POLYMORPHISM; ACTIVATION; MELOXICAM

Authors

Shakhtshneider T.P. ^1,2,3 , Myz S.A. ^1,2,3 , Dyakonova M.A. ^1,2,3 , Boldyrev V.V. ^1,2,3 , Boldyreva E.V. ^1,2,3 , Nizovskii A.I. ⁴ , Kalinkin A.V. ⁴ , Kumar Rakesh ⁵

Affiliations

1	Institute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russian Federation
2	Research and Education Center Molecular Design and Ecologically Safe Technologies, Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russian Federation
3	Novosibirsk State University
4	Boreskov Institute of Catalysis, pr. Lavrentieva, 5, Novosibirsk, 630090, Russian Federation
5	National Metallurgical Laboratory, Jamshedpur-831 007, India

Funding (3)

1	Civilian Research and Development Foundation	RUX0-008-NO-06
2	Russian Foundation for Basic Research	09-03-92658
3	Department of Science and Technology

The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites. The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites. The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms. It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form.

Shakhtshneider T.P. , Myz S.A. , Dyakonova M.A. , Boldyrev V.V. , Boldyreva E.V. , Nizovskii A.I. , Kalinkin A.V. , Kumar R.
Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

Acta Physica Polonica A. 2011. V.120. N2. P.272-278. DOI: 10.12693/APhysPolA.120.272 WOS Scopus РИНЦ ANCAN OpenAlex

Full text from publisher

Published print:

Aug 1, 2011

Web of science:	WOS:000291836900015
Scopus:	2-s2.0-79960127422
Elibrary:	16992834
Chemical Abstracts:	2011:808503
Chemical Abstracts (print):	155:312358
OpenAlex:	W1603431807

DB	Citing
Web of science	16
Scopus	21
Elibrary	24
OpenAlex	20