Blood Serum and Erythrocyte Lipidomic Profiling Revealed Diagnostic Biomarkers in Patients with Early Stages of CRC and Adenomatous Polyps | Sciact - CRIS-система Института катализа

Blood Serum and Erythrocyte Lipidomic Profiling Revealed Diagnostic Biomarkers in Patients with Early Stages of CRC and Adenomatous Polyps Тезисы доклада

Конференция

28th United European Gastroenterology Week Virtual 2020
11-13 окт. 2020 , Online

Журнал

United European Gastroenterology Journal
ISSN: 2050-6406 , E-ISSN: 2050-6414

Вых. Данные

Год: 2020, Том: 8, Номер: 8_suppl, Страницы: 527 Страниц : 1 DOI: 10.1177/2050640620927345

Ключевые слова

COLORECTAL CANCER, FATTY ACIDS, EARLY STAGES

Авторы

Kruchinina M.V. ¹ , Gromov A.A. ¹ , Kruchinin V.N. ² , Shashkov M.V. ³ , Sokolova A.S. ⁴ , Shestov A.A. ⁵

Организации

1	Research Institute of Internal and Preventive Medicine, Branch of the Institute of Cytology & Genetics, Siberian Branch of the Russian Academy of Sciences
2	Rzhanov Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences
3	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences
4	Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, 9, Academician Lavrentiev Ave., Novosibirsk, 630090
5	Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States

Objective: A) To investigate if discriminant lipidomics could be used as a potential diagnostic tool for early stages of colorectal cancer (esCRC) and precancerous condition adenomatous polyps (AP). B) to create a list of fatty acids (FAs) in the erythrocyte membranes (Er) and in blood serum (BS), the levels of which can be used as biomarkers of esCRC and AP. C) To investigate the accuracy of machine learning methods and different FAs sets to classify esCRC and AP patients from healthy individuals. Aims & Methods: A total of 65 CRC patients with disease stages 1 and 2, as well as 25 patients with adenomatous polyps, and 35 conditionally healthy persons were included. The analysis of the Er and BS fatty acids (FAs) composition has been carried out using a gas chromatography-mass spectrometry (GC/MS) system based on the Agilent 7000B Triple Quadrupole (USA). Measured sets of FAs and two machine learning methods (support vector machine and random forest) were used to classify esCRC and AP patients from healthy participants as well as esCRC patients from AP. Results: We have determined the levels of >30 FAs and their ratios in BS and Er membranes for the proband groups...

Kruchinina M.V. , Gromov A.A. , Kruchinin V.N. , Shashkov M.V. , Sokolova A.S. , Shestov A.A.
Blood Serum and Erythrocyte Lipidomic Profiling Revealed Diagnostic Biomarkers in Patients with Early Stages of CRC and Adenomatous Polyps

United European Gastroenterology Journal. 2020. V.8. N8_suppl. P.527. DOI: 10.1177/2050640620927345 Scopus РИНЦ OpenAlex

Полный текст от издателя

Опубликована в печати:	1 окт. 2020 г.
Опубликована online:	10 окт. 2020 г.

Scopus:	2-s2.0-85092753863
РИНЦ:	44090671
OpenAlex:	W3212599147

БД	Цитирований
Scopus	4
OpenAlex	10