New Diagnostic Capabilities for Crohns disease: Use of Fatty Acid Profiles of Erythrocyte Membranes and Blood Serum | Sciact - CRIS-system of Boreskov Institute of Catalysis

New Diagnostic Capabilities for Crohns disease: Use of Fatty Acid Profiles of Erythrocyte Membranes and Blood Serum Conference Abstracts

Conference

28th United European Gastroenterology Week Virtual 2020
11-13 Oct 2020 , Online

Journal

United European Gastroenterology Journal
ISSN: 2050-6406 , E-ISSN: 2050-6414

Output data

Year: 2020, Volume: 7, Number: 58, Pages: 334-335 Pages count : 2

Tags

CROHN'S DISEASE, FATTY ACIDS, DIAGNOSIS

Authors

Kruchinina M.V. ¹ , Gromov A.A. ¹ , Svetlova I.O. ¹ , Azgaldyan A.V. ¹ , Kruchinin V.N. ² , Shashkov M.V. ³ , Sokolova A.S. ⁴

Affiliations

1	Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Gen, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
2	Rzhanov Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
3	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
4	Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation

The fatty acids, in particular the n-3 and n-6 PUFAs, mediate a number of key biological processes, including production of eicosanoids, inflammation, physiological processes in the cell membrane, gene regulation and expression [1]. Aims & Methods: The purpose of this research is to investigate the features of the fatty acid composition of erythrocyte membranes (Er) and blood serum (BS) among patients with Crohn´s Disease (CD) for possible use in differential diagnosis. We have examined 22 patients with CD, 21 patients with inflammatory bowel diseases unclassified (IBDU) (35.2+4.7 years), and 20 healthy individuals, which are comparable in age and gender to the main groups. The study of the composition of fatty acids (FAs) of Er and BS has been carried out using a gas chromatography-mass spectrometry (GC/MS) system based on the Agilent 7000B Triple Quadrupole (USA). Results: The levels of most saturated, monounsaturated omega-9 (palmitoleic C16:1n-9, oleinic C18:1n-9), omega-6 PUFAs have been significantly higher among patients with Crohn´s disease, and the predominant part of omega-3 (including eicosapentaenoic (C20:5 n-3), docosapentaenoic (C22:5 n-3), docosahexaenoic (C22:6 n-3) is lower than among healthy individuals (p< 0.001-0.05)...

Kruchinina M.V. , Gromov A.A. , Svetlova I.O. , Azgaldyan A.V. , Kruchinin V.N. , Shashkov M.V. , Sokolova A.S.
New Diagnostic Capabilities for Crohns disease: Use of Fatty Acid Profiles of Erythrocyte Membranes and Blood Serum
United European Gastroenterology Journal. 2020. V.7. N58. P.334-335. РИНЦ

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