Reductive Amination of 5-acetoxymethylfurfural over Pt/Al2O3 Catalyst in a Flow Reactor Full article
| Journal |
Molecular Catalysis
ISSN: 2468-8231 |
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| Output data | Year: 2021, Volume: 499, Article number : 111297, Pages count : 5 DOI: 10.1016/j.mcat.2020.111297 | ||||
| Tags | Reductive amination; 5-Acetoxymethylfurfural; Pt/Al2O3 catalyst; Primary amines; Flow hydrogenation | ||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 |
Russian Science Foundation FWF Austrian Science Fund |
20-43-05002 |
Abstract:
Aminomethylhydroxymethylfuran derivatives are well known for their pharmaceutical activities. In this work, the two-step one-pot procedure for the synthesis of N-substituted 5-(acetoxymethyl)-2-furfuryl amines was proposed, which includes two successive reactions: the condensation of 5-acetoxymethylfurfural (AMF) with primary amines and the reduction of obtained imines with hydrogen over supported metal catalysts in a flow reactor. The comparison of the properties of Au, Pd and Pt catalysts in the hydrogenation of imine obtained by reaction of AMF with aniline showed that Pt-based catalysts (both Pt/Al2O3 and Pt/C) are highly active and provide high selectivity and stability, while Pd and Au nanoparticles supported on γ-alumina and carbon show low selectivity. A wide range of N-substituted 5-(acetoxymethyl)-2-furfuryl amines was synthesized in good to excellent yields using Pt/Al2O3 catalyst and methanol as a solvent.
Cite:
Nuzhdin A.L.
, Simonov P.A.
, Bukhtiyarova G.A.
, Eltsov I.V.
, Bukhtiyarov V.I.
Reductive Amination of 5-acetoxymethylfurfural over Pt/Al2O3 Catalyst in a Flow Reactor
Molecular Catalysis. 2021.
V.499. 111297
:1-5. DOI: 10.1016/j.mcat.2020.111297
WOS
Scopus
РИНЦ
AN
OpenAlex
Reductive Amination of 5-acetoxymethylfurfural over Pt/Al2O3 Catalyst in a Flow Reactor
Molecular Catalysis. 2021.
V.499. 111297
:1-5. DOI: 10.1016/j.mcat.2020.111297
WOS
Scopus
РИНЦ
AN
OpenAlex
Files:
Full text from publisher
Dates:
| Submitted: | Aug 9, 2020 |
| Accepted: | Oct 28, 2020 |
| Published online: | Nov 19, 2020 |
| Published print: | Jan 1, 2021 |
Identifiers:
| Web of science: | WOS:000604630900002 |
| Scopus: | 2-s2.0-85097078757 |
| Elibrary: | 45113329 |
| Chemical Abstracts: | 2020:2438497 |
| OpenAlex: | W3104978513 |