Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents | Sciact - CRIS-система Института катализа

Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents Научная публикация

Журнал

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Вых. Данные

Год: 2020, Том: 27, Номер: 8, Страницы: 2774-2781 Страниц : 8 DOI: 10.1002/chem.202004168

Ключевые слова

flammability; fluorine; hyperpolarization; inhalable anesthetics; parahydrogen

Авторы

Joalland Baptiste ¹ , Ariyasingha Nuwandi M. ¹ , Younes Hassan R. ¹ , Nantogma Shiraz ¹ , Salnikov Oleg G. ^2,3,4 , Chukanov Nikita V. ^2,3 , Kovtunov Kirill V. ^2,3 , Koptyug Igor V. ^2,3 , Gelovani Juri G. ^1,5 , Chekmenev Eduard Y. ^1,6

Организации

1	Department of Chemistry, Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202 (USA)
2	International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk (Russia)
3	Department of Natural Sciences, Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk (Russia)
4	Boreskov Institute of Catalysis SB RAS, Acad. Lavrentiev Prospekt 5, 630090 Novosibirsk (Russia)
5	United Arab Emirates University, Al Ain (United Arab Emirates)
6	Russian Academy of Sciences, Leninskiy Prospekt 14, Moscow, 119991 (Russia)

Информация о финансировании (9)

1	National Science Foundation	CHE-1904780
2	United States Department of Defense	W81XWH-15-1-0271
3	National Institutes of Health	1R21HL154032-01
4	Российский фонд фундаментальных исследований	17-54-33037
5	Российский фонд фундаментальных исследований	19-53-12013 (АААА-А19-119040990042-7)
6	Российский фонд фундаментальных исследований	19-29-10003 (АААА-А19-119100890052-8)
7	Российский фонд фундаментальных исследований	19-33-60045
8	Федеральное агентство научных организаций России	0333-2016-0002 (АААА-А16-116121510087-5)
9	United States Department of Defense	W81XWH-20-1-0576

Many MRI contrast agents formed with the parahydrogen‐induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high‐throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.

Joalland B. , Ariyasingha N.M. , Younes H.R. , Nantogma S. , Salnikov O.G. , Chukanov N.V. , Kovtunov K.V. , Koptyug I.V. , Gelovani J.G. , Chekmenev E.Y.
Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents
Chemistry - A European Journal. 2020. V.27. N8. P.2774-2781. DOI: 10.1002/chem.202004168 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	13 сент. 2020 г.
Принята к публикации:	28 окт. 2020 г.
Опубликована online:	7 янв. 2021 г.
Опубликована в печати:	5 февр. 2021 г.

Web of science:	WOS:000614897200026
Scopus:	2-s2.0-85097366415
РИНЦ:	45091508
Chemical Abstracts:	2021:84025
PMID (PubMed):	33112442
OpenAlex:	W3096159834

БД	Цитирований
Web of science	8
РИНЦ	9
Scopus	10
OpenAlex	12