Synthesis and 15N NMR Signal Amplification by Reversible Exchange of [15N]Dalfampridine at Microtesla Magnetic Fields | Sciact - CRIS-система Института катализа

Synthesis and 15N NMR Signal Amplification by Reversible Exchange of [15N]Dalfampridine at Microtesla Magnetic Fields Научная публикация

Журнал

ChemPhysChem
ISSN: 1439-4235 , E-ISSN: 1439-7641

Вых. Данные

Год: 2021, Том: 22, Номер: 10, Страницы: 960-967 Страниц : 8 DOI: 10.1002/cphc.202100109

Ключевые слова

SABRE; parahydrogen; hyperpolarization; NMR spectroscopy; isotopic labeling

Авторы

Chukanov Nikita V. ^1,2 , Salnikov Oleg G. ^1,2,3 , Trofimov Ivan A. ^1,2 , Kabir Mohammad S.H. ⁴ , Kovtunov Kirill V. ^1,2 , Koptyug Igor V. ¹ , Chekmenev Eduard Y. ^4,5

Организации

1	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk, Russia
2	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
3	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk, Russia
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States
5	Russian Academy of Sciences, 14 Leninskiy Prospekt, 119991 Moscow, Russia

Информация о финансировании (5)

1	Российский фонд фундаментальных исследований	19-53-12013 (АААА-А19-119040990042-7)
2	Федеральное агентство научных организаций России	0333-2016-0002 (АААА-А16-116121510087-5)
3	Российский фонд фундаментальных исследований	19-43-540004 (АААА-А19-119090590009-9)
4	National Science Foundation	CHE-1904780
5	National Institute of Biomedical Imaging and Bioengineering	1R01EB029829

Signal Amplification by Reversible Exchange (SABRE) technique enables nuclear spin hyperpolarization of wide range of compounds using parahydrogen. Here we present the synthetic approach to prepare 15N‐labeled [15N]dalfampridine (4‐amino[15N]pyridine) utilized as a drug to reduce the symptoms of multiple sclerosis. The synthesized compound was hyperpolarized using SABRE at microtesla magnetic fields (SABRE‐SHEATH technique) with up to 2.0 % 15N polarization. The 7‐hour‐long activation of SABRE pre‐catalyst [Ir(IMes)(COD)Cl] in the presence of [15N]dalfampridine can be remedied by the use of pyridine co‐ligand for catalyst activation while retaining the 15N polarization levels of [15N]dalfampridine. The effects of experimental conditions such as polarization transfer magnetic field, temperature, concentration, parahydrogen flow rate and pressure on 15N polarization levels of free and equatorial catalyst‐bound [15N]dalfampridine were investigated. Moreover, we studied 15N polarization build‐up and decay at magnetic field of less than 0.04 μT as well as 15N polarization decay at the Earth's magnetic field and at 1.4 T.

Chukanov N.V. , Salnikov O.G. , Trofimov I.A. , Kabir M.S.H. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
Synthesis and 15N NMR Signal Amplification by Reversible Exchange of [15N]Dalfampridine at Microtesla Magnetic Fields
ChemPhysChem. 2021. V.22. N10. P.960-967. DOI: 10.1002/cphc.202100109 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	11 февр. 2021 г.
Принята к публикации:	18 мар. 2021 г.
Опубликована online:	1 апр. 2021 г.
Опубликована в печати:	17 мая 2021 г.

Web of science:	WOS:000640660200001
Scopus:	2-s2.0-85104688462
РИНЦ:	46028545
Chemical Abstracts:	2021:901324
PMID (PubMed):	33738893
OpenAlex:	W3139010388

БД	Цитирований
Web of science	9
Scopus	9
РИНЦ	10
OpenAlex	12