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To Rebound or...Rebound? Evidence for the “Alternative Rebound” Mechanism in C–H Oxidations by the Systems Nonheme Mn Complex/H2O2/Carboxylic Acid Full article

Journal ACS Catalysis
ISSN: 2155-5435
Output data Year: 2021, Volume: 11, Number: 9, Pages: 5517-5524 Pages count : 8 DOI: 10.1021/acscatal.1c00811
Tags biomimetic catalysis; C-H activation; hydrogen peroxide; manganese; mechanism
Authors Ottenbacher Roman V. 1,2 , Bryliakova Anna A. 1 , Shashkov Mikhail V. 1,2 , Talsi Evgenii P. 2 , Bryliakov Konstantin P. 1,2
Affiliations
1 Novosibirsk State University, Pirogova 1, Novosibirsk 630090, Russian Federation
2 Boreskov Institute of Catalysis, Pr. Lavrentieva 5, Novosibirsk 630090, Russian Federation

Funding (1)

1 Russian Science Foundation 20-13-00032 (АААА-А20-120071590003-2)

Abstract: In this work, it has been shown that aliphatic C-H oxidations by bioinspired catalyst systems Mn aminopyridine complex/H2O2/carboxylic acid in acetonitrile afford predominantly a mixture of the corresponding alcohol and the ester. The alcohol/ester ratio is higher for catalysts bearing electron-donating groups at the aminopyridine core. Isotopic labeling studies witness that the oxygen atom of the alcohol originates from the H2O2 molecule, while the ester oxygen comes exclusively from the acid. Oxidation of ethylbenzene in the presence of acetic acid affords enantiomerically enriched 1-phenylethanol and 1-phenyl acetate, with close enantioselectivities and the same sign of absolute chirality. Experimental data and density functional theory calculations provide evidence in favor of the rate-limiting benzylic H atom abstraction by the high-spin (S = 1) [LMnV(O)OAc](2+) active species followed by competitive OH/OC(O)R rebound. This mechanism has been unprecedented for C-H oxidations catalyzed by bioinspired Mn complexes. The trends governing the alcohol/ester ratios have been rationalized in terms of steric properties of the catalyst, acid, and substrate.
Cite: Ottenbacher R.V. , Bryliakova A.A. , Shashkov M.V. , Talsi E.P. , Bryliakov K.P.
To Rebound or...Rebound? Evidence for the “Alternative Rebound” Mechanism in C–H Oxidations by the Systems Nonheme Mn Complex/H2O2/Carboxylic Acid
ACS Catalysis. 2021. V.11. N9. P.5517-5524. DOI: 10.1021/acscatal.1c00811 WOS Scopus РИНЦ ANCAN OpenAlex
Dates:
Submitted: Feb 20, 2021
Accepted: Apr 12, 2021
Published online: Apr 21, 2021
Published print: May 7, 2021
Identifiers:
Web of science: WOS:000649106200052
Scopus: 2-s2.0-85106399321
Elibrary: 46077556
Chemical Abstracts: 2021:916704
Chemical Abstracts (print): 176:215244
OpenAlex: W3155999820
Citing:
DB Citing
Scopus 33
Web of science 32
Elibrary 29
OpenAlex 35
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