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Synergism of the Cytopathic Effect of Synchrotron Radiation and Manganese Oxide Nanoparticles on the Growth of Human Glioblastoma Cells In Vitro Научная публикация

Журнал Nanotechnologies in Russia
ISSN: 1995-0780 , E-ISSN: 1995-0799
Вых. Данные Год: 2020, Том: 15, Номер: 11-12, Страницы: 819-827 Страниц : 9 DOI: 10.1134/S1995078020060166
Ключевые слова Brain; Cell culture; Irradiation; Manganese oxide; Nanoparticles; Oxide minerals; Synchrotron radiation; Synchrotrons; Tumors
Авторы Razumov I.A. 1,4 , Troitsky S.Y. 2 , Zavjalov E.L. 1,4 , Solovieva O.I. 1,4 , Goldenberg B.G. 3 , Legkodymov A.A. 3 , Lemzyakov A.G. 3 , Kuper K.E. 3
Организации
1 Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
2 Federal Research Center Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
3 Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
4 Novosibirsk State University, Novosibirsk, Russia

Информация о финансировании (1)

1 Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) 0324-2019-0041 (RFMEFI62119X0023)

Реферат: A binary cytopathic effect (CPE%) of synchrotron radiation (SR) and manganese oxide nanoparticles (MnO NP) on human glioblastoma U87MG, U-251MG, and A-172 cell lines was studied in vitro. After incubation of the cells with MnO NP at a concentration of 5 and 50 µmol for 18–24 h, irradiation of glioblastoma cells at the source of SR VEPP-4 was carried out. X-ray irradiation doses 0, 1, 2, 4 Gy were used. The results were estimated using a light microscopy, determination of CPE% on the counter (Countess, Invitrogen), and the clonogenic test. It was revealed that the preliminary incubation of glioblastoma cell lines with MnO NP causes an increase in CPE of external SR at a dose 1, 2, and 4 Gy on the glioblastoma cells by 25, 50, and 100%. This effect allows to reduce the radiation dose by 2–3 times, maintaining the efficiency of the effect. At the same time, the period of vital activity of tumor cells under a combined effect of SR and NP is reduced by 18–36 h. Probably, a synergism of the combination of MnO NP and SR will provide new opportunities for the development of a model for the treatment of brain tumors. © 2020, Pleiades Publishing, Ltd.
Библиографическая ссылка: Razumov I.A. , Troitsky S.Y. , Zavjalov E.L. , Solovieva O.I. , Goldenberg B.G. , Legkodymov A.A. , Lemzyakov A.G. , Kuper K.E.
Synergism of the Cytopathic Effect of Synchrotron Radiation and Manganese Oxide Nanoparticles on the Growth of Human Glioblastoma Cells In Vitro
Nanotechnologies in Russia. 2020. V.15. N11-12. P.819-827. DOI: 10.1134/S1995078020060166 WOS Scopus РИНЦ CAPlusCA OpenAlex
Оригинальная: Разумов И.А. , Троицкий С.Ю. , Завьялов Е.Л. , Соловьева О.И. , Гольденберг Б.Г. , Легкодымов А.А. , Лемзяков А.Г. , Купер К.Е.
Синергизм цитопатического действия синхротронного излучения и наночастиц оксида марганца на рост in vitro клеток глиобластом человека
Российские нанотехнологии. 2020. Т.15. №6. С.824–832. DOI: 10.1134/S1992722320060163 РИНЦ OpenAlex
Даты:
Поступила в редакцию: 8 сент. 2020 г.
Принята к публикации: 1 окт. 2020 г.
Опубликована online: 5 мая 2021 г.
Опубликована в печати: 1 нояб. 2021 г.
Идентификаторы БД:
Web of science: WOS:000647627900020
Scopus: 2-s2.0-85105487391
РИНЦ: 46048849
Chemical Abstracts: 2021:1896835
Chemical Abstracts (print): 176:182115
OpenAlex: W3157803103
Цитирование в БД:
БД Цитирований
Scopus 1
Web of science 1
OpenAlex 1
Альметрики: