Synthetic Approaches for N-15-Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for N-15 NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields Научная публикация
| Журнал |
Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765 |
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| Вых. Данные | Год: 2021, Том: 27, Номер: 38, Страницы: 9727 – 9736 Страниц : 10 DOI: 10.1002/chem.202100212 | ||||||||||||||
| Ключевые слова | Hyperpolarization; magnetic resonance imaging; NMR spectroscopy; parahydrogen; spectroscopy | ||||||||||||||
| Авторы |
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| Организации |
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Информация о финансировании (7)
| 1 | National Science Foundation | CHE-1904780 |
| 2 | National Institutes of Health | 1R21CA220137 |
| 3 | National Institute of Biomedical Imaging and Bioengineering | 1R01EB029829 |
| 4 | Российский фонд фундаментальных исследований | 19-43-540004 (АААА-А19-119090590009-9) |
| 5 | Российский фонд фундаментальных исследований | 19-29-10003 (АААА-А19-119100890052-8) |
| 6 | Российский фонд фундаментальных исследований | 19-53-12013 (АААА-А19-119040990042-7) |
| 7 | Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) |
Реферат:
NMR hyperpolarization techniques enhance nuclear spin polarization by several orders of magnitude resulting in corresponding sensitivity gains. This enormous sensitivity gain enables new applications ranging from studies of small molecules by using high-resolution NMR spectroscopy to real-time metabolic imaging in vivo. Several hyperpolarization techniques exist for hyperpolarization of a large repertoire of nuclear spins, although the C-13 and N-15 sites of biocompatible agents are the key targets due to their widespread use in biochemical pathways. Moreover, their long T-1 allows hyperpolarized states to be retained for up to tens of minutes. Signal amplification by reversible exchange (SABRE) is a low-cost and ultrafast hyperpolarization technique that has been shown to be versatile for the hyperpolarization of N-15 nuclei. Although large sensitivity gains are enabled by hyperpolarization, N-15 natural abundance is only similar to 0.4 %, so isotopic labeling of the molecules to be hyperpolarized is required in order to take full advantage of the hyperpolarized state. Herein, we describe selected advances in the preparation of N-15-labeled compounds with the primary emphasis on using these compounds for SABRE polarization in microtesla magnetic fields through spontaneous polarization transfer from parahydrogen. Also, these principles can certainly be applied for hyperpolarization of these emerging contrast agents using dynamic nuclear polarization and other techniques.
Библиографическая ссылка:
Chukanov N.V.
, Shchepin R.V.
, Joshi S.M.
, Kabir M.S.H.
, Salnikov O.G.
, Svyatova A.
, Koptyug I.V.
, Gelovani J.G.
, Chekmenev E.Y.
Synthetic Approaches for N-15-Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for N-15 NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields
Chemistry - A European Journal. 2021. V.27. N38. P.9727 – 9736. DOI: 10.1002/chem.202100212 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Synthetic Approaches for N-15-Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for N-15 NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields
Chemistry - A European Journal. 2021. V.27. N38. P.9727 – 9736. DOI: 10.1002/chem.202100212 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Даты:
| Поступила в редакцию: | 19 янв. 2021 г. |
| Принята к публикации: | 15 апр. 2021 г. |
| Опубликована online: | 21 мая 2021 г. |
| Опубликована в печати: | 7 июл. 2021 г. |
Идентификаторы БД:
| Web of science: | WOS:000652786700001 |
| Scopus: | 2-s2.0-85105905816 |
| РИНЦ: | 46075879 |
| Chemical Abstracts: | 2021:1184483 |
| PMID (PubMed): | 33856077 |
| OpenAlex: | W3154792603 |