Biocompatability of the Complex Aluminum Oxide and Polydimethylsiloxane Modified with Carbon Nanofibre | Sciact - CRIS-system of Boreskov Institute of Catalysis

Biocompatability of the Complex Aluminum Oxide and Polydimethylsiloxane Modified with Carbon Nanofibre Conference Abstracts

Conference

Computational Technologies in Cognitive Science, Genomics and Biomedicine : 2021 IEEE Ural-Siberian Conference
26-28 May 2021 , Novosibirsk – Yekaterinburg

Source

2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), May 26–28, 2021, Novosibirsk – Yekaterinburg, Russia : Proceedings
Compilation, 2021. ISBN 978-1-6654-3149-1.

Output data

Year: 2021, Article number : 9496014, Pages count : 4 DOI: 10.1109/CSGB53040.2021.9496014

Tags

apoptosis; carbon nanofibers; human bone marrow mesenchymal stem cells; nitrogen oxide production; polydimethylsiloxane; porous aluminum oxide; proliferation; structure

Authors

Lykov Alexander ¹ , Rachkovskaya Lubov ¹ , Poveshchenko Olga ¹ , Rachkovsky Edmund ¹ , Surovtseva Maria ¹ , Kim Irina ¹ , Bondarenko Natalia ¹ , Volodin Alexander ² , Bauman Yuri ² , Mishakov Ilya ² , Vedyagin Aleksey ²

Affiliations

1	Siberian Branch of Russian Academy of Sciences, Researcher Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Novosibirsk, Russia
2	Siberian Branch of Russian Academy of Sciences, Boreskov Institute of Catalysis, Novosibirsk, Russia

The introduction of nanomaterials in medical technologies requires a more thorough study of their toxicity, as data are accumulating on the presence of toxic properties in carbon nanotubes and carbon nanofibers. Attention should also be paid to the possibility of linking the toxicity of carbon nanomaterials with an admixture of metals used in the synthesis of carbon nanofibers (CNF) as catalysts and included in the structure of nanomaterials. The CNF was prepared from methane, ethylene, and C3 -C4 hydrocarbon gases by chemical deposition from the gas phase on Ni-Cu/Al2O3 , and 90Ni-10Cu catalysts. The gamma-aluminum oxide-polydimethylsiloxanecarbon nanofiber (Al2O 3 /PDMS/CNF) samples was prepared in aqueous phase. Using low-temperature sorption on nitrogen (BET method) studied porous structure and specific surface of the CNF. The MTT test, nitrogen oxide production, and apoptosis rate were used to estimate compatibility of Al 2 O 3 /PDMS/CNF with mesenchymal stem cells. It was shown that type of catalyst, raw material, and condition of temperature mode, and time exposure influenced on the characteristics of obtained CNF. Samples of Al2O3 /PDMS/CNF have not affected human bone marrow mesenchymal stem cells (hBM-MSCs) proliferation and nitrogen oxide production. Whereas some Al2O3 /PDMS/CNF samples significantly increased hBM-MSCs apoptosis. Thus, we have no obtained significant toxicity of the Al2O3 /PDMS/CNF samples on hBM-MSCs.

Lykov A. , Rachkovskaya L. , Poveshchenko O. , Rachkovsky E. , Surovtseva M. , Kim I. , Bondarenko N. , Volodin A. , Bauman Y. , Mishakov I. , Vedyagin A.
Biocompatability of the Complex Aluminum Oxide and Polydimethylsiloxane Modified with Carbon Nanofibre
In compilation 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), May 26–28, 2021, Novosibirsk – Yekaterinburg, Russia : Proceedings. 2021. – C.180-183. – ISBN 978-1-6654-3149-1. DOI: 10.1109/CSGB53040.2021.9496014 Scopus РИНЦ OpenAlex

Scopus:	2-s2.0-85112374308
Elibrary:	46961320
OpenAlex:	W3183611120

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