Parahydrogen-Induced Polarization Relayed via Proton Exchange | Sciact - CRIS-system of Boreskov Institute of Catalysis

Parahydrogen-Induced Polarization Relayed via Proton Exchange Full article

Journal

Journal of the American Chemical Society
ISSN: 0002-7863 , E-ISSN: 1520-5126

Output data

Year: 2021, Volume: 143, Number: 34, Pages: 13694–13700 Pages count : 7 DOI: 10.1021/jacs.1c05254

Tags

Alcohols, Reaction mechanisms, Polarization, Ethanol, Molecules

Authors

Them Kolja ¹ , Ellermann Frowin ¹ , Pravdivtsev Andrey N. ¹ , Salnikov Oleg G. ^2,3,4 , Skovpin Ivan V. ^2,3 , Koptyug Igor V. ^2,3 , Herges Rainer ⁵ , Hövener Jan-Bernd ¹

Affiliations

1	Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, 24118 Kiel, Germany
2	International Tomography Center, SB RAS, Novosibirsk 630090, Russia
3	Novosibirsk State University, Novosibirsk 630090, Russia
4	Boreskov Institute of Catalysis SB RAS, Novosibirsk 630090, Russia
5	Otto-Diels-Institute for Organic Chemistry, Christian-Albrechts-University, Kiel, 24118, Germany

Funding (6)

1	Russian Foundation for Basic Research	19-53-12013 (АААА-А19-119040990042-7)
2	German Research Foundation	HO 4604/2-2
3	German Research Foundation	GRK 2154/1-2019
4	German Research Foundation	PMI 2167
5	Federal Ministry of Education and Research	01ZX1915C
6	European Commission	122-09-053

The hyperpolarization of nuclear spins is a game-changing technology that enables hitherto inaccessible applications for magnetic resonance in chemistry and biomedicine. Despite significant advances and discoveries in the past, however, the quest to establish efficient and effective hyperpolarization methods continues. Here, we describe a new method that combines the advantages of direct parahydrogenation, high polarization (P), fast reaction, and low cost with the broad applicability of polarization transfer via proton exchange. We identified the system propargyl alcohol + pH2 → allyl alcohol to yield 1H polarization in excess of P ≈ 13% by using only 50% enriched pH2 at a pressure of ≈1 bar. The polarization was then successfully relayed via proton exchange from allyl alcohol to various target molecules. The polarizations of water and alcohols (as target molecules) approached P ≈ 1% even at high molar concentrations of 100 mM. Lactate, glucose, and pyruvic acid were also polarized, but to a lesser extent. Several potential improvements of the methodology are discussed. Thus, the parahydrogen-induced hyperpolarization relayed via proton exchange (PHIP-X) is a promising approach to polarize numerous molecules which participate in proton exchange and support new applications for magnetic resonance. © 2021 The Authors. Published by American Chemical Society.

Them K. , Ellermann F. , Pravdivtsev A.N. , Salnikov O.G. , Skovpin I.V. , Koptyug I.V. , Herges R. , Hövener J-B.
Parahydrogen-Induced Polarization Relayed via Proton Exchange
Journal of the American Chemical Society. 2021. V.143. N34. P.13694–13700. DOI: 10.1021/jacs.1c05254 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	May 28, 2021
Published online:	Aug 18, 2021
Published print:	Sep 1, 2021

Web of science:	WOS:000704514200027
Scopus:	2-s2.0-85114174069
Elibrary:	47051979
Chemical Abstracts:	2021:1803237
PMID:	34406748
OpenAlex:	W3196034809

DB	Citing
Scopus	25
Web of science	26
Elibrary	22
OpenAlex	33