On the Origin of Better Hemocompatibility of the BCxNyOz Coatings | Sciact - CRIS-система Института катализа

On the Origin of Better Hemocompatibility of the BCxNyOz Coatings Научная публикация

Журнал

Applied Surface Science
ISSN: 0169-4332

Вых. Данные

Год: 2022, Том: 576, Номер статьи : 151760, Страниц : 14 DOI: 10.1016/j.apsusc.2021.151760

Ключевые слова

BCxNyOz; Bioactive coatings; Hemocompatibility; Metallic implant; Ti-6Al-4V

Авторы

Bhaskar Nitu ¹ , Sulyaeva Veronica ² , Gatapova Elizaveta ³ , Kaichev Vasily ⁴ , Khomyakov Maxim ⁵ , Kolodin Alexey ² , Kosinova Marina ² , Basu Bikramjit ¹

Организации

1	Materials Research Center, Indian Institute of Science, Bangalore, Karnataka 560012, India
2	Nikolaev Institute of Inorganic Chemistry SB RAS, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russia
3	Kutateladze Institute of Thermophysics SB RAS, 1, Acad. Lavrentiev Ave., Novosibirsk 630090, Russia
4	Boreskov Institute of Catalysis SB RAS, 5, Acad. Lavrentiev Ave., Novosibirsk 630090, Russia
5	Institute of Laser Physics SB RAS, 15B, Acad. Lavrentiev Ave., Novosibirsk 630090, Russia

Информация о финансировании (2)

1	Department of Science and Technology	SR/WOS-A/LS-513/2017
2	Российский фонд фундаментальных исследований Department of Science and Technology	18-53-80016 (АААА-А18-118091290003-8) / DST/IMRCD/BRICS/PilotCall2/SCBCPCVD/2018

The development of hemocompatible coatings on metallic implants is one of the challenges for blood-contacting implantable devices. In this paper, we investigated the blood-material interaction of BCxNyOz coatings deposited on Ti-6Al-4V substrates, using reactive radiofrequency magnetron sputtering technique with variation in nitrogen (N2) flow rate. A series of experiments, including hemolysis tests, erythrocytes, and platelets adhesion and activation analysis, dynamic blood coagulation, and plasma recalcification time tests, were performed to understand the blood-material interactions, qualitatively and quantitatively. The results revealed that the degree of hemolysis on all the samples was below 2.5%, suggesting their favourable interaction with RBCs. The interactions between erythrocytes and platelets with all the BCxNyOz coatings were reduced significantly compared to Ti-6Al-4V. BCxNyOz coatings could substantially delay the time of blood coagulation to the period of 60 min. The plasma recalcification time of coatings was also increased significantly. An effort has been made to rationalize the difference in hardness or blood compatibility parameters in terms of [N]/[B] or [N]/[C] ratio. The present study conclusively establishes that BCxNyOz coatings can significantly enhance hemocompatibility, thereby opening up a myriad of biomedical applications. © 2021

Bhaskar N. , Sulyaeva V. , Gatapova E. , Kaichev V. , Khomyakov M. , Kolodin A. , Kosinova M. , Basu B.
On the Origin of Better Hemocompatibility of the BCxNyOz Coatings
Applied Surface Science. 2022. V.576. 151760 :1-14. DOI: 10.1016/j.apsusc.2021.151760 WOS Scopus РИНЦ CAPlus OpenAlex

Поступила в редакцию:	16 июл. 2021 г.
Принята к публикации:	27 окт. 2021 г.
Опубликована online:	31 окт. 2021 г.
Опубликована в печати:	1 февр. 2022 г.

Web of science:	WOS:000729414000004
Scopus:	2-s2.0-85118859142
РИНЦ:	47524568
Chemical Abstracts:	2021:2511931
OpenAlex:	W3210777082

БД	Цитирований
Scopus	9
Web of science	8
РИНЦ	5
OpenAlex	12